Different effects of scopolamine on learning, memory, and nitric oxide metabolite levels in hippocampal tissues of ovariectomized and Sham-operated rats

被引：39
|
作者：
Azizi-Malekabadi, Hamid [2 ]
Hosseini, Mahmoud [1 ,3 ]
Soukhtanloo, Mohammad [4 ]
Sadeghian, Reihaneh [5 ]
Fereidoni, Masoud [5 ]
Khodabandehloo, Fatimeh [6 ]
机构：
[1] Mashhad Univ Med Sci, Sch Med, Neurosci Res Ctr, Mashhad, Iran
[2] Islamic Azad Univ, Fac Basic Sci, Khorasgan Branch, Esfahan, Iran
[3] Mashhad Univ Med Sci, Dept Physiol, Mashhad, Iran
[4] Mashhad Univ Med Sci, Dept Biochem, Sch Med, Mashhad, Iran
[5] Ferdowsi Univ Mashhad, Dept Biol, Fac Sci, Mashhad, Iran
[6] AJA Univ Med Sci, Dept Physiol, Sch Med, Tehran, Iran
来源：
ARQUIVOS DE NEURO-PSIQUIATRIA | 2012年 / 70卷 / 06期
关键词：
Morris water maze; scopolamine; ovariectomized; rat; hippocampus; nitric oxide; MORRIS WATER MAZE; MESSENGER-RNA; WORKING-MEMORY; L-ARGININE; CHOLINE-ACETYLTRANSFERASE; ESTROGEN REPLACEMENT; PREFRONTAL CORTEX; OVARIAN HORMONES; BASAL FOREBRAIN; DIAGONAL BAND;
D O I：
10.1590/S0004-282X2012000600012
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Different effects of scopolamine on learning, memory, and nitric oxide (NO) metabolites in hippocampal tissues of ovariectomized (OVX) and sham-operated rats were investigated. The animals in the Sham-Scopolamine (Sham-Sco) and OVX-Scopolamine (OVX-Sco) Groups were treated with 2 mg/kg scopolamine before undergoing the Morris water maze, while the animals in the Sham and OVX Groups received saline. The time latency and path length were significantly higher in both the Sham-Sco and the OVX-Sco Groups, in comparison with the Sham and OVX Groups, respectively (p<0.001). Significantly lower NO metabolite levels in the hippocampi of the Sham-Sco Group were observed, compared with the Sham Group (p<0.001), while there was no significant difference between the OVX-Sco and OVX Groups. The decreased NO level in the hippocampus may play a role in the learning and memory deficits induced by scopolamine. However, it seems that the effect of scopolamine on hippocampal NO differs between situations of presence and absence of ovarian hormones.
引用
收藏
页码：447 / 452
页数：6
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