An Unexpected Reaction of Arenesulfonyl Cyanides with Allylic Alcohols: Preparation of Trisubstituted Allyl Sulfones

被引：69

作者：

Reddy, Leleti Rajender ^{[1
]}

Hu, Bin ^{[1
]}

Prashad, Mahavir ^{[1
]}

Prasad, Kapa ^{[1
]}

机构：

[1] Novartis Pharmaceut, Chem & Analyt Dev, E Hanover, NJ 07936 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 01期

关键词：

allyl sulfones; bases; Baylis-Hillman adducts; synthetic methods; BAYLIS-HILLMAN ADDUCTS;

D O I：

10.1002/anie.200803836

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) An efficient and practical protocol for the highly selective preparation of substituted allyl sulfones has been developed. Arenesulfonyl cyanides, Baylis-Hillman adducts, and simple allylic alcohols give an unforeseen outcome (see scheme). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：172 / 174

页数：3

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