Clinical Characteristics of Idiopathic Ulcerative Colitis in Children

Introduction Idiopathic ulcerative colitis (IUC) represents a rare disease of childhood. It usually occurs at age over 10 years, and below that exceptionally rarely. Objective The aim of the paper was to analyze the clinical signs, symptoms and therapeutic procedures in children with WC. Methods The aims of the paper were based on a sample of 17 children (11 male and 6 female, mean age 11.90 +/- 3.50 years; range 3.8-17.5 years) with IUC. The disease diagnosis was based on characteristic endoscopic and pathohistological findings. Results The basic signs of disease involved chronic mucosal haemorrhagic diarrhoea which was confirmed in 16 of 17 patients, with body weight deficiency (10), recurrent abdominal pain (6), fever (5), slowed down maturation (5), marked anorexia (4), and tendsmus (3). Two patients had recurrent aphthous ' stomatitis, 2 anal fissUres, 2 arthralgia, one autoimmune hepatitis and one pyoderrna gangrenosum. None of the children had longitudinal growth retardation. Elevated sedimentation rate and C-reactive protein in blood were registered in 11, sideropenia in 10, anaemia in 6 and hypoalbuminemia in 3 patients. The remission of proctosigmoiditis and left sided colitis was achieved with aminosalicylates; and of panccilitis with the combination of arninosalicylates and glucocorticoids, except in cases of steroid-depen' dent colitis, which additionally required azathioprine. Conclusion The main signs of IUC in children are chronic mucous haemorrhagic diarrhoea, body weight loss and sideropenic anaemia, while the basic therapy consists of an-linosalicylates, and in more severe Cases of the disease the initial use of glucocorticoids and later azathioprine.