High-resolution computed tomography scan and airway remodeling in children with severe asthma

被引:60
|
作者
de Blic, J
Tillie-Leblond, I
Ernond, S
Mahut, B
Duy, TLD
Scheinmann, P
机构
[1] Univ Paris 05, Serv Pneumol & Allergol Pediat, Hop Necker Enfants Malad, F-75015 Paris, France
[2] Inst Pasteur, INSERM, U416, F-59019 Lille, France
[3] Hop Necker Enfants Malad, Serv Radiol, F-75015 Paris, France
[4] Hop Europeen Georges Pompidou, Lab Explorat Fonct Resp Radio Isotope, Paris, France
关键词
Severe asthma; nitrous oxide; HRCT scan; bronchial wall thickening; reticular basement membrane; remodeling; airway inflammation; ECP; IFN-gamma; IL-4;
D O I
10.1016/j.jaci.2005.07.009
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background: Children with severe asthma have a significantly higher bronchial wall thickness (BWT) on high-resolution computed tomography scan than control children. Objective: We sought to determine whether a BWT score correlates with markers of airway remodeling and inflammation. Methods: In 37 children with severe asthma, we determined reticular basement membrane thickness; number of intraepithelial neutrophils and eosinophils on bronchial biopsy; IFN-gamma, IL-4, IL-5, and eosinophil cationic protein levels and IFN-gamma/IL-4 ratio on bronchoalveolar lavage specimen; and alveolar nitric oxide (NO) concentration and the maximum airway wall NO flux. Results: The BWT score significantly correlated with reticular basement membrane thickening (r = 0.34; P =.04) and NO production by the airway wall (r = 0.45; P =.02). The correlation with the eosinophil cationic protein level was just significant (r = 0.40; P =.05), whereas there was no correlation with IFN-gamma/IL-4 ratio (r = -0.31; P = .08). The BWT score did not correlate with FEV1 or forced expiratory flow at 25% to 75% of forced vital capacity. Conclusion: High-resolution computed tomography scan is a noninvasive technique that might be valuable for quantifying airway remodeling in children with severe asthma. The new generations of multislice computed tomography scanners will allow higher definition and lower radiation exposure and probably give a better assessment of airway remodeling and efficacy of treatment in children with asthma.
引用
收藏
页码:750 / 754
页数:5
相关论文
共 50 条
  • [1] Influence of omalizumab therapy on airway remodeling assessed with high-resolution computed tomography (HRCT) in severe allergic asthma patients
    Przybyszowski, Marek
    Paciorek, Kinga
    Zastrzezynska, Weronika
    Gawlewicz-Mroczka, Agnieszka
    Trojan-Krolikowska, Anna
    Orlowska, Anna
    Soja, Jerzy
    Pawlik, Wieslaw
    Sladek, Krzysztof
    [J]. ADVANCES IN RESPIRATORY MEDICINE, 2018, 86 (06) : 282 - 290
  • [2] Findings in Chest High-Resolution Computed Tomography in Severe Asthma
    Ortega, Extremera A. M.
    Lozano, Moreno L.
    Jimenez, Gonzalez O. M.
    Segade, Borja J.
    Romo, Joyanes J. B.
    Rodriguez, Munoz J. R.
    Feo-Brito, F.
    Bonilla, Galindo
    [J]. JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, 2022, 32 (02) : 146 - 147
  • [3] Airway Remodeling in Asthma: Evaluation in 5 Consecutive Bronchial Generations by Using High-Resolution Computed Tomography
    Jiang, Dan
    Wang, Zhimin
    Yu, Nan
    Shen, Cong
    Deng, Lei
    Guo, Youmin
    [J]. RESPIRATORY CARE, 2018, 63 (11) : 1399 - 1406
  • [4] Quantitative computed tomography imaging of airway remodeling in severe asthma
    Grenier, Philippe A.
    Fetita, Catalin I.
    Brillet, Pierre-Yves
    [J]. QUANTITATIVE IMAGING IN MEDICINE AND SURGERY, 2016, 6 (01) : 76 - 83
  • [5] Airway remodeling assessed by high-resolution computed tomography in patients with asthma:relationship to biological markers in induced sputum
    吴世满
    [J]. China Medical Abstracts (Internal Medicine), 2013, 30 (01) : 40 - 41
  • [6] Airway remodelling assessed by sputum and high-resolution computed tomography in asthma and COPD
    Vignola, AM
    Paganin, F
    Capieu, L
    Scichilone, N
    Bellia, M
    Maakel, L
    Bellia, V
    Godard, P
    Bousquet, J
    Chanez, P
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2004, 24 (06) : 910 - 917
  • [7] Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes
    Gupta, Sumit
    Siddiqui, Salman
    Haldar, Pranab
    Entwisle, James J.
    Mawby, Dean
    Wardlaw, Andrew J.
    Bradding, Peter
    Pavord, Ian D.
    Green, Ruth H.
    Brightling, Christopher E.
    [J]. THORAX, 2010, 65 (09) : 775 - 781
  • [8] Chest high-resolution computed tomography: Clinical utility in a severe asthma unit
    De La Cruz Martinez, C. A.
    Guillen-Vera, D.
    Revilla Ostolaza, Y.
    Alonso Charterina, S.
    Morales Ruiz, R.
    Perez Nunez, M.
    Diaz Campos, R.
    Melero, C.
    Fernandez, C.
    Bobolea, I
    [J]. ALLERGY, 2017, 72 : 560 - 561
  • [9] Peripheral airways obstruction on high-resolution computed tomography in chronic severe asthma
    Carr, DH
    Hibon, S
    Rubens, M
    Chung, KF
    [J]. RESPIRATORY MEDICINE, 1998, 92 (03) : 448 - 453
  • [10] A morphologic study of the airway structure abnormalities in patients with asthma by high-resolution computed tomography
    Wang, Dan
    Luo, Jian
    Du, Wen
    Zhang, Lan-Lan
    He, Li-Xiu
    Liu, Chun-Tao
    [J]. JOURNAL OF THORACIC DISEASE, 2016, 8 (10) : 2697 - 2708