Catechol-O-methyltransferase gene val158met polymorphism and depressive symptoms during early childhood

被引:18
|
作者
Sheikh, Haroon I. [1 ]
Kryski, Katie R. [1 ]
Smith, Heather J. [1 ]
Dougherty, Lea R. [2 ]
Klein, Daniel N. [3 ]
Bufferd, Sara J. [3 ]
Singh, Shiva M. [1 ]
Hayden, Elizabeth P. [1 ]
机构
[1] Univ Western Ontario, London, ON N6A 5B7, Canada
[2] Univ Maryland, College Pk, MD 20742 USA
[3] SUNY Stony Brook, Stony Brook, NY 11794 USA
基金
加拿大健康研究院;
关键词
catechol-O-methyltransferase; val158met; anxiety; depression; internalizing; replication; LIFETIME MAJOR DEPRESSION; PSYCHIATRIC-DISORDERS; PANIC DISORDER; COMT GENE; FUNCTIONAL POLYMORPHISM; MOOD DISORDERS; MENTAL-HEALTH; ANXIETY; ASSOCIATION; POPULATION;
D O I
10.1002/ajmg.b.32141
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Catechol-O-Methyltransferase (COMT) is a critical regulator of catecholamine levels in the brain. A functional polymorphism of the COMT gene, val158met, has been linked to internalizing symptoms (i.e., depression and anxiety) in adolescents and adults. We extended this research by investigating whether the val158met polymorphism was associated with childhood symptoms of depression and anxiety in two independent samples of young children (Ns=476 and 409). In both samples, preschool-aged children were genotyped for the COMT val158met polymorphism. Symptoms of psychopathology were assessed via parent interviews and primary caregiver reports. In both samples, children homozygous for the val allele had higher levels of depressive symptoms compared to children with at least one copy of the met allele. Our findings extend previous research in older participants by showing links between the COMT val158met polymorphism and internalizing symptoms in early childhood. (c) 2013 Wiley Periodicals, Inc.
引用
收藏
页码:245 / 252
页数:8
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