This paper investigates the surjective linear isometrics between the differentiable function spaces C-0(n)(Omega, E) and C-0(m)(Sigma, F) (where Omega, Sigma are open subsets of Euclidean spaces and E, F are reflexive, strictly convex Banach spaces), and show that such isometrics can be written as weighted composition operators. (C) 2015 Elsevier Inc. All rights reserved.