Regiospecific synthesis of 1,4,5-trisubstituted 1,2,3-triazoles via enolate-azide cycloaddition between 1,3-dicarbonyl compounds and aryl azides

被引：12

作者：

Nelson, Ronald ^{[1
]}

Kesternich, Victor ^{[1
]}

Perez-Fehrmann, Marcia ^{[1
]}

Jaldin, Sally ^{[1
]}

Marcourt, Laurence ^{[2
]}

Christen, Philippe ^{[2
]}

机构：

[1] Univ Catolica Norte, Dept Quim, Fac Ciencias, Antofagasta, Chile

[2] Univ Lausanne, Univ Geneva, Sch Pharmaceut Sci, Quai Ernest Ansermet 30, CH-1211 Geneva 4, Switzerland

来源：

JOURNAL OF CHEMICAL RESEARCH | 2016年 / 08期

关键词：

1,4,5-trisubstituted 1H-1,2,3-triazoles; regioselective synthesis of 1,2,3-triazole; enolate-azide cycloaddition; potassium carbonateassisted synthesis; AZIDOPHENYL ARYLSELENIDES; INHIBITORY-ACTIVITY; DERIVATIVES; TUBERCULOSIS; ANTIPLATELET; KETONES; SAR;

D O I：

10.3184/174751916X14656662266973

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A cycloaddition reaction at room temperature between aryl azides and 1,3-dicarbonyl compounds in the presence of potassium carbonate in dimethylsulphoxide yielded 10 4-ethoxycarbonyl-1-aryl-5-methyl-1H-1,2,3-triazoles and seven other closely-related compounds. The 1,2,3-triazoles, nine of which are new, were obtained in good to high yields and only the 1,4-regioisomers were formed.

引用

页码：453 / 457

页数：5

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