Autophagy, signaling and obesity

被引：59
|
作者：
Lavallard, Vanessa J. [1 ,2 ]
Meijer, Alfred J. [4 ]
Codogno, Patrice [5 ]
Gual, Philippe [1 ,2 ,3 ]
机构：
[1] INSERM, U1065, Equipe Complicat Hepat Obesite 8, Batiment Univ ARCHIMED,151 Route St Antoine Gines, F-06204 Nice 03, France
[2] Univ Nice Sophia Antipolis, Fac Med, Nice, France
[3] Hop Archet, Ctr Hosp Univ Nice, Dept Digestif, Nice, France
[4] Univ Amsterdam, Acad Med Ctr, Dept Med Biochem, NL-1105 AZ Amsterdam, Netherlands
[5] Univ Paris 11, INSERM, U984, F-92296 Chatenay Malabry, France
来源：
PHARMACOLOGICAL RESEARCH | 2012年 / 66卷 / 06期
关键词：
Autophagy; Lipophagy; Liver; Adipose tissue; Pancreas; NAFLD; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; TRANSFER-RNA SYNTHETASE; INDUCED CELL-DEATH; AMINO-ACID; OXIDATIVE STRESS; ER STRESS; INSULIN-RESISTANCE; BECLIN; MITOCHONDRIAL DYSFUNCTION;
D O I：
10.1016/j.phrs.2012.09.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Autophagy is a cellular pathway crucial for development, differentiation, survival and homeostasis. Autophagy can provide protection against aging and a number of pathologies such as cancer, neurodegeneration, cardiac disease and infection. Recent studies have reported new functions of autophagy in the regulation of cellular processes such as lipid metabolism and insulin sensitivity. Important links between the regulation of autophagy and obesity including food intake, adipose tissue development, beta cell function, insulin sensitivity and hepatic steatosis exist. This review will provide insight into the current understanding of autophagy, its regulation, and its role in the complications associated with obesity. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：513 / 525
页数：13
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