Progesterone regulation of synaptic transmission and plasticity in rodent hippocampus

被引：40
|
作者：
Foy, Michael R. [1 ]
Akopian, Garnik [2 ]
Thompson, Richard F. [2 ]
机构：
[1] Loyola Marymount Univ, Dept Psychol, Los Angeles, CA 90045 USA
[2] Univ So Calif, Neurosci Program, Los Angeles, CA 90089 USA
来源：
LEARNING & MEMORY | 2008年 / 15卷 / 11期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1101/lm.1124708
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Ovarian hormones influence memory formation by eliciting changes in neural activity. The effects of various concentrations of progesterone (P4) on synaptic transmission and plasticity associated with long-term potentiation (LTP) and long-term depression (LTD) were studied using in vitro hippocampal slices. Extracellular studies show that the highest concentration of P4 tested (10(-6) M) decreased the baseline synaptic transmission and magnitude of LTP, but did not affect LTD. Intracellular studies suggest the P4 effect to be mediated, at least in part, by GABA(A) activity. These results establish a general effect of P4 on synaptic transmission, multiple forms of synaptic plasticity, and a possible mechanism of P4 action in hippocampus.
引用
收藏
页码：820 / 822
页数：3
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