Update on the breast cancer susceptibility gene BRCA 1

被引：0
|
作者：
Weber, B [1 ]
机构：
[1] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA
来源：
22ND CONGRESS OF THE INTERNATIONAL ASSOCIATION FOR BREAST CANCER RESEARCH | 1999年
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中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BRCA1 is a breast cancer susceptibility gene that was isolated in 1994. It is thought to function as a classic tumor suppressor gene, with loss of both alleles required for tumor initiation. While the function of BRCA1 has not yet been fully elucidated, recent studies support a role in cell cycling and cellular response to DNA damage. In addition, there are data to suggest that BRCA1 may be a component of the Rad51-p53-p21 cellular pathway that recognizes damaged DNA and produces a growth arrest to allow DNA repair to occur, or induces apoptosis.
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页码：71 / 76
页数：6
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