The Safety, Tolerability, and Subject-Rated Effects of Acute Intranasal Cocaine Administration During Aripiprazole Maintenance II: Increased Aripipirazole Dose and Maintenance Period

被引：18

作者：

Lile, Joshua A. ^{[1
]}

Stoops, William W. ^{[1
]}

Hays, Lon R. ^{[2
,4
]}

Rush, Craig R. ^{[1
,2
,3
]}

机构：

[1] Univ Kentucky, Med Ctr, Dept Behav Sci, Lexington, KY 40536 USA

[2] Univ Kentucky, Med Ctr, Dept Psychiat, Lexington, KY 40536 USA

[3] Univ Kentucky, Dept Psychol, Lexington, KY 40536 USA

[4] Univ Kentucky, Dept Internal Med, Lexington, KY 40536 USA

来源：

AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE | 2008年 / 34卷 / 06期

关键词：

aripiprazole; cocaine; pharmacotherapy; physiological effects; subjective effects;

D O I：

10.1080/00952990802308262

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Objectives: This experiment determined the safety and tolerability of intranasal cocaine during aripiprazole maintenance. Methods: Six cocaine-dependent human subjects were maintained on aripiprazole (15 mg) and placebo for 10 days in counterbalanced order prior to assessing the physiological and subject-rated effects of intranasal cocaine. Results: Intranasal cocaine produced prototypical stimulant-like effects (e.g., increased blood pressure and heart rate, increased subject ratings of Like Drug and Stimulated), and aripiprazole enhanced these effects on several measures. Conclusions: Aripiprazole (15 mg/day) is safe and tolerable when combined with cocaine; however, the usefulness of aripiprazole as a treatment for cocaine-use disorders remains to be determined.

引用

页码：721 / 729

页数：9

共 6 条

[1] The safety, tolerability, and subject-rated effects of acute intranasal cocaine administration during aripiprazole maintenance
Stoops, William W.
Lile, Joshua A.
Lofwall, Michelle R.
Rush, Craig R.
[J]. AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE, 2007, 33 (06): : 769 - 776
[2] Safety, tolerability and subject-rated effects of acute intranasal cocaine administration during atomoxetine maintenance
Stoops, William W.
Blackburn, John W.
Hudson, David A.
Hays, Lon R.
Rush, Craig R.
[J]. DRUG AND ALCOHOL DEPENDENCE, 2008, 92 (1-3) : 282 - 285
[3] Safety and tolerability of intranasal cocaine during phendimetrazine maintenance
William W. Stoops
Justin C. Strickland
Lon R. Hays
Abner O. Rayapati
Joshua A. Lile
Craig R. Rush
[J]. Psychopharmacology, 2016, 233 : 2055 - 2063
[4] Safety and tolerability of intranasal cocaine during phendimetrazine maintenance
Stoops, William W.
Strickland, Justin C.
Hays, Lon R.
Rayapati, Abner O.
Lile, Joshua A.
Rush, Craig R.
[J]. PSYCHOPHARMACOLOGY, 2016, 233 (11) : 2055 - 2063
[5] Relationship between intranasal cocaine self-administration and subject-rated effects: predictors of cocaine taking on progressive-ratio schedules
Strickland, Justin C.
Lile, Joshua A.
Rush, Craig R.
Stoops, William W.
[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2014, 29 (04) : 342 - 350
[6] Cocaine effects during D-amphetamine maintenance: A human laboratory analysis of safety, tolerability and efficacy
Rush, Craig R.
Stoops, William W.
Hays, Lon R.
[J]. DRUG AND ALCOHOL DEPENDENCE, 2009, 99 (1-3) : 261 - 271

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