Pallidal deep brain stimulation modulates cortical excitability and plasticity

被引：49

作者：

Ni, Zhen ^{[1
,6
]}

Kim, Sang Jin ^{[1
]}

Phielipp, Nicolas ^{[1
]}

Ghosh, Soumya ^{[1
]}

Udupa, Kaviraja ^{[1
]}

Gunraj, Carolyn A. ^{[1
]}

Saha, Utpal ^{[1
]}

Hodaie, Mojgan ^{[2
]}

Kalia, Suneil K. ^{[2
]}

Lozano, Andres M. ^{[2
]}

Lee, Darrin J. ^{[2
]}

Moro, Elena ^{[1
,3
]}

Fasano, Alfonso ^{[1
,4
]}

Hallett, Mark ^{[5
]}

Lang, Anthony E. ^{[1
,4
]}

Chen, Robert ^{[1
,4
]}

机构：

[1] Univ Toronto, Div Neurol, Dept Med, Toronto, ON, Canada

[2] Univ Toronto, Dept Surg, Div Neurosurg, Toronto, ON, Canada

[3] Grenoble Alpes Univ, Univ Hosp Ctr Grenoble, Natl Inst Hlth & Med Res, Neurol Dept,U1214, Grenoble, France

[4] Toronto Western Hosp, Edmond J Safra Program Parkinsons Dis, Toronto, ON, Canada

[5] NINDS, Human Motor Control Sect, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

[6] NIH, Bldg 10, Bethesda, MD 20892 USA

来源：

ANNALS OF NEUROLOGY | 2018年 / 83卷 / 02期

基金：

加拿大健康研究院;

关键词：

TRANSCRANIAL MAGNETIC STIMULATION; HUMAN MOTOR CORTEX; BASAL GANGLIA; EVOKED-POTENTIALS; INHIBITION; CIRCUITS; DYSTONIA; CONNECTIVITY; INDUCTION; NEURONS;

D O I：

10.1002/ana.25156

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

ObjectiveInternal globus pallidus (GPi) deep brain stimulation (DBS) relieves symptoms in dystonia patients. However, the physiological effects produced by GPi DBS are not fully understood. In particular, how a single-pulse GPi DBS changes cortical circuits has never been investigated. We studied the modulation of motor cortical excitability and plasticity with single-pulse GPi DBS in dystonia patients with bilateral implantation of GPi DBS. MethodsThe cortical evoked potentials from DBS were recorded with electroencephalography. Transcranial magnetic stimulation with a conditioning test paired-pulse paradigm was used to investigate the effect of GPi DBS on the primary motor cortex. How GPi DBS might modulate the motor cortical plasticity was tested using a paired associative stimulation paradigm with repetitive pairs of GPi DBS and motor cortical stimulation at specific time intervals. ResultsGPi stimulation produced 2 peaks of cortical evoked potentials with latencies of approximate to 10 and approximate to 25 milliseconds in the motor cortical area. Cortical facilitation was observed at approximate to 10 milliseconds after single-pulse GPi DBS, and cortical inhibition was observed after a approximate to 25-millisecond interval. Repetitive pairs of GPi stimulation with cortical stimulation at these 2 time intervals produced long-term potentiation-like effects in the motor cortex. InterpretationSingle-pulse DBS modulates cortical excitability and plasticity at specific time intervals. These effects may be related to the mechanism of action of DBS. Combination of DBS with cortical stimulation with appropriate timing has therapeutic potential and could be explored in the future as a method to enhance the effects of neuromodulation for neurological and psychiatric diseases. Ann Neurol 2018;83:352-362

引用

页码：352 / 362

页数：11

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