Interaction of DNA/polycation complexes with phospholipids:: Stabilizing strategy for gene delivery

被引：5

作者：

Zintchenko, A ^{[1
]}

Konák, C ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Macromol Chem, CR-16206 Prague 6, Czech Republic

来源：

MACROMOLECULAR BIOSCIENCE | 2005年 / 5卷 / 12期

关键词：

gene delivery systems; light scattering; phospholipids; polyelectrolyte complexes;

D O I：

10.1002/mabi.200500159

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction between negatively charged lipid vesicles and positively charged DNA/polylysine complexes was studied. The interaction does not lead to release of DNA from the initial complexes. The particles formed are easy to prepare, they have slight negative charge, small dimensions and show good stability in physiological NaCl solution. Such properties might indicate that stabilization of the particles by lipid coating might be a potent strategy, alternative to PEGylation of DNA/polycation complexes.

引用

页码：1169 / 1174

页数：6

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