Cantharidin-Based Small Molecules as Potential Therapeutic Agents

被引：86

作者：

Puerto Galvis, Carlos E. ^{[1
]}

Vargas Mendez, Leonor Y. ^{[2
]}

Kouznetsov, Vladimir V. ^{[1
]}

机构：

[1] Univ Ind Santander, Escuela Quim, Lab Quim Organ & Biomol, Bucaramanga 678, Colombia

[2] Univ Santo Tomas, Fac Quim Ambiental, Grp Invest Ambientales, Bucaramanga 1076, Colombia

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2013年 / 82卷 / 05期

关键词：

anticancer activity; blister beetles; cantharidin analogs; Diels-Alder cycloaddition reactions; drug design and development; protein phosphatases inhibitory activity; DIELS-ALDER REACTIONS; NEOPYROCHROA FLABELLATA CANTHARIDIN; SUBSTITUTED AROMATIC-AMINES; NORCANTHARIDIN ANALOGS; ANTICANCER ACTIVITY; PROTEIN PHOSPHATASES; NATURAL-PRODUCTS; BLISTER BEETLE; DRUG DISCOVERY; IN-VITRO;

D O I：

10.1111/cbdd.12180

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical and pharmacological information on cantharidin-based small molecules was analyzed. The review summarizes new facts about blister beetles' metabolites for the period 2006-2012. General synthetic approaches to cantharidin-based small molecules as well as their chemical transformations and biological activities related to cantharidin, norcantharidin, cantharidimide, and norcantharimide analogs, especially their inhibitory activity of phosphoprotein phosphatases in cancer treatment, were discussed in this mini review, which could help to design new small molecule modulators for other biological models.

引用

页码：477 / 499

页数：23

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