Whole-Body 177Lu-Prostate-Specific Membrane Antigen Scan Pattern With Excess Free 177Lu-Chloride in a Metastatic Castration-Resistant Prostate Cancer Patient

被引：0
|
作者：
Askari, Emran [1 ]
Moghadam, Soroush Zarehparvar [1 ]
Divband, Ghasemali [1 ]
Aryana, Kamran [1 ]
机构：
[1] Mashhad Univ Med Sci, Nucl Med Res Ctr, Mashhad, Razavi Khorasan, Iran
来源：
CLINICAL NUCLEAR MEDICINE | 2020年 / 45卷 / 10期
关键词：
Lu-177-PSMA; free lutetium; mCRPC; RLT;
D O I：
10.1097/RLU.0000000000003167
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
A 56-year-old man with metastatic castration-resistant prostate cancer was referred for radioligand therapy with 177Lu-prostate-specific membrane antigen. In the third cycle, a posttherapy whole-body scan showed unexpected skeletal and joint uptake apart from his known metastatic lesions. This observation raised suspicion for possible impurity (mainly free lutetium) in the applied radiopharmaceutical product. After contacting the radiopharmaceutical company, we were informed that the radiochemical purity of the used batch of 177Lu-prostate-specific membrane antigen had been 95%. This is the first report of excess free lutetium scan pattern and its complications in a patient undergoing radioligand therapy. © Wolters Kluwer Health, Inc. All rights reserved.
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收藏
页码：805 / 807
页数：3
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