Physostigmine antagonizes ketamine-induced noradrenaline release from the medial prefrontal cortex in rats

被引：21

作者：

Kubota, T ^{[1
]}

Hirota, K ^{[1
]}

Anzawa, N ^{[1
]}

Yoshida, H ^{[1
]}

Kushikata, T ^{[1
]}

Matsuki, A ^{[1
]}

机构：

[1] Hirosaki Univ, Sch Med, Dept Anesthesiol, Hirosaki, Aomori 0368216, Japan

来源：

BRAIN RESEARCH | 1999年 / 840卷 / 1-2期

关键词：

ketamine; physostigmine; medial prefrontal cortex; noradrenaline; rat;

D O I：

10.1016/S0006-8993(99)01793-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Physostigmine is known to antagonize ketamine anesthesia. In this study, effects of physostigmine (0.1 mg kg(-1) i.p.) on ketamine (100 mg kg(-1) i.p.)-induced anesthesia time and noradrenaline release from the medial prefrontal cortex in rats were examined. Ketamine produced anesthesia for 27 +/- 1 min and increased noradrenaline release to 405% of the basal. Physostigmine significantly reduced anesthesia time to 23 +/- 1 min(p < 0.05), and noradrenaline to 248% (p < 0.05). Therefore, noradrenaline release may play an important role in ketamine anesthesia. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：175 / 178

页数：4

共 50 条

[1] Inhibitory effect of clonidine on ketamine-induced norepinephrine release from the medial prefrontal cortex in rats
Kubota, T
Hirota, K
Yoshida, H
Takahashi, S
Ohkawa, H
Anzawa, N
Kushikata, T
Matsuki, A
[J]. BRITISH JOURNAL OF ANAESTHESIA, 1999, 83 (06) : 945 - 947
[2] Effects of ketamine and pentobarbital on noradrenaline release from the medial prefrontal cortex in rats
Takeshi Kubota
Noriyuki Anzawa
Kazuyoshi Hirota
Hitoshi Yoshida
Tetsuya Kushikata
Akitomo Matsuki
[J]. Canadian Journal of Anaesthesia, 1999, 46 : 388 - 392
[3] Effects of ketamine and pentobarbital on noradrenaline release from the medial prefrontal cortex in rats
Kubota, T
Anzawa, N
Hirota, K
Yoshida, H
Kushikata, T
Matsuki, A
[J]. CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 1999, 46 (04): : 388 - 392
[4] Effects of sedatives on noradrenaline release from the medial prefrontal cortex in rats
Takeshi Kubota
Kazuyoshi Hirota
Hitoshi Yoshida
Satoshi Takahashi
Noriyuki Anzawa
Hirofumi Ohkawa
Tetsuya Kushikata
Akitomo Matsuki
[J]. Psychopharmacology, 1999, 146 : 335 - 338
[5] Effects of sedatives on noradrenaline release from the medial prefrontal cortex in rats
Kubota, T
Hirota, K
Yoshida, H
Takahashi, S
Anzawa, N
Ohkawa, H
Kushikata, T
Matsuki, A
[J]. PSYCHOPHARMACOLOGY, 1999, 146 (03) : 335 - 338
[6] RECOVERY FROM KETAMINE-INDUCED AMNESIA BY BLOCKADE OF GABA-A RECEPTOR IN THE MEDIAL PREFRONTAL CORTEX OF MICE
Farahmandfar, Maryam
Akbarabadi, Ardeshir
Bakhtazad, Atefeh
Zarrindast, Mohammad-Reza
[J]. NEUROSCIENCE, 2017, 344 : 48 - 55
[7] CRF RECEPTOR ANTAGONIST ATTENUATES STRESS-INDUCED NORADRENALINE RELEASE IN THE MEDIAL PREFRONTAL CORTEX OF RATS
SHIMIZU, N
NAKANE, H
HORI, T
HAYASHI, Y
[J]. BRAIN RESEARCH, 1994, 654 (01) : 145 - 148
[8] MECHANISMS UNDERLYING KETAMINE-INDUCED SYNAPTIC DEPRESSION IN RAT HIPPOCAMPUS-MEDIAL PREFRONTAL CORTEX PATHWAY
Kamiyama, H.
Matsumoto, M.
Otani, S.
Kimura, S. -I.
Shimamura, K. -I.
Ishikawa, S.
Yanagawa, Y.
Togashi, H.
[J]. NEUROSCIENCE, 2011, 177 : 159 - 169
[9] The influence of dopaminergic system in medial prefrontal cortex on ketamine-induced amnesia in passive avoidance task in mice
Farahmandfar, Maryam
Bakhtazad, Atefeh
Akbarabadi, Ardeshir
Zarrindast, Mohammad-Reza
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2016, 781 : 45 - 52
[10] Pharmacokinetics-Pharmacodynamics Dissociation Indicative of Ketamine-Induced Plasticity as Revealed by Ultrasonic Ketamine Uncaging in Rat Medial Prefrontal Cortex
Yu, Brenda
Roy, Kanchan Sinha
Purohit, Mahaveer
Xiang, Yun
Azadian, Matine
Taoube, Ali
Kwan, Audrey
Lopez, Diego Gomez
Airan, Raag
[J]. NEUROPSYCHOPHARMACOLOGY, 2023, 48 : 277 - 278

← 1 2 3 4 5 →