Facile and Versatile Synthesis of Alkyl and Aryl Isothiocyanates by Using Triphosgene and Cosolvent

被引：18

作者：

Liu, Pengfei ^{[1
]}

Li, Chunyan ^{[1
]}

Zhang, Jingwei ^{[1
]}

Xu, Xiaoyong ^{[1
]}

机构：

[1] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2013年 / 43卷 / 24期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

Amines; co-solvent; dehydrosulfurization; isothiocyanates; triphosgene; CELLS; PROTEINS; REAGENTS;

D O I：

10.1080/00397911.2013.783600

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient method for the conversion of alkyl and aryl amines to isothiocyanates via dithiocarbamates has been developed using (CH3)(2)CO-CS2 as co-solvent and triphosgene as dehydrosulfurization reagent. High yields, mild reaction conditions and excellent functional group compatibility make it become a versatile synthetic method for the preparation of isothiocyanates compared with reported methods. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

引用

页码：3342 / 3351

页数：10

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