Cambridge Hybrid Closed-Loop System in Very Young Children With Type 1 Diabetes Reduces Caregivers' Fear of Hypoglycemia and Improves Their Well-being

被引：15

作者：

de Beaufort, Carine ^{[1
,2
,3
]}

Schierloh, Ulrike ^{[1
]}

Thankamony, Ajay ^{[4
]}

Ware, Julia ^{[4
,5
]}

Wilinska, Malgorzata E. ^{[5
]}

Froehlich-Reiterer, Elke ^{[6
]}

Kapellen, Thomas M. ^{[7
,8
]}

Rami-Merhar, Birgit ^{[9
]}

Hofer, Sabine E. ^{[10
]}

Campbell, Fiona M. ^{[11
]}

Yong, James ^{[11
]}

Bocchino, Laura E. ^{[12
]}

Sibayan, Judy ^{[12
]}

Lawton, Julia ^{[13
]}

Roze, Stephane ^{[14
]}

Fritsch, Maria ^{[6
]}

Thiele, Alena ^{[7
]}

Allen, Janet M. ^{[4
]}

Boughton, Charlotte ^{[4
]}

Mader, Julia K. ^{[15
]}

Kollman, Craig ^{[12
]}

Hovorka, Roman ^{[4
,5
]}

Pit-ten Cate, Ineke M. ^{[16
]}

机构：

[1] Ctr Hosp Luxembourg, Diabet & Endocrine Care Clin Pediat, Luxembourg, Luxembourg

[2] Univ Luxembourg, Fac Sci Technol & Med, Esch Belval, Luxembourg

[3] Univ Ziekenhuis Brussel, Free Univ Hosp, Dept Pediat, Brussels, Belgium

[4] Univ Cambridge, Wellcome Trust Med Res Council, Inst Metab Sci, Cambridge, England

[5] Univ Cambridge, Dept Paediat, Cambridge, England

[6] Med Univ Graz, Dept Pediat & Adolescent Med, Graz, Austria

[7] Univ Leipzig, Hosp Children & Adolescents, Leipzig, Germany

[8] Hosp Children & Adolescents Nicolausholz, Bad Kosen, Germany

[9] Med Univ Vienna, Dept Pediat & Adolescent Med, Vienna, Austria

[10] Med Univ Innsbruck, Dept Pediat 1, Innsbruck, Austria

[11] Leeds Childrens Hosp, Dept Paediat Diabet, Leeds, W Yorkshire, England

[12] Jaeb Ctr Hlth Res, Tampa, FL USA

[13] Univ Edinburgh, Usher Inst, Edinburgh, Midlothian, Scotland

[14] Vyoo Agcy Sarl, Lyon, France

[15] Med Univ Graz, Dept Internal Med, Div Endocrinol & Diabetol, Graz, Austria

[16] Univ Luxembourg, Luxembourg Ctr Educ Assessment, Esch Belval, Luxembourg

来源：

DIABETES CARE | 2022年 / 45卷 / 12期

基金：

英国惠康基金;

关键词：

PARENTS;

D O I：

10.2337/dc22-0693

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE To evaluate the impact of CamAPS FX hybrid closed-loop (HCL) automated insulin delivery in very young children with type 1 diabetes (T1D) on caregivers' well-being, fear of hypoglycemia, and sleepiness. RESEARCH DESIGN AND METHODS We conducted a multinational, open-label, randomized crossover study. Children (age 1-7 years) with T1D received treatment for two 4-month periods in random order, comparing HCL with sensor augmented pump (control). At baseline and after each treatment period, caregivers were invited to complete World Health Organization-Five Well-Being Index, Hypoglycemia Fear Survey, and Epworth Sleepiness Scale questionnaires. RESULTS Caregivers of 74 children (mean SD age 5 +/- 2 years and baseline HbA1(c) 7.3 +/- 0.7%; 42% female) participated. Results revealed significantly lower scores for hypoglycemia fear (P < 0.001) and higher scores for well-being (P < 0.001) after HCL treatment. A trend toward a reduction in sleepiness score was observed (P = 0.09). CONCLUSIONS Our results suggest better well-being and less hypoglycemia fear in caregivers of very young children with T1D on CamAPS FX HCL.

引用

页码：3050 / 3053

页数：4

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