Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins

被引：40
|
作者：
Fruchey, Erin R. [1 ]
Monks, Brendan M. [1 ]
Patterson, Andrea M. [1 ]
Cook, Silas P. [1 ]
机构：
[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 17期
基金：
美国国家科学基金会;
关键词：
CROSS-COUPLING REACTIONS; ALKENYL HALIDES; RADICALS; CYCLIZATION; IODIDES; COMPLEXES; LIGANDS; STEREOCHEMISTRY; MECHANISM; BONDS;
D O I：
10.1021/ol4018694
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new route to trisubstituted olefins through a palladium-catalyzed alkyne insertion/reduction reaction with unactivated alkyl iodides is reported. The reaction proceeds under mild conditions and tolerates a range of functional groups and substitution patterns. Preliminary mechanistic inquiry suggests that the transformation may proceed through a hybrid radical/organometallic pathway.
引用
收藏
页码：4362 / 4365
页数：4
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