HLA frequencies and associations in cystic fibrosis

被引：2

作者：

Adriaanse, M. P. M. ^{[1
,2
]}

Vreugdenhil, A. C. E. ^{[1
,2
]}

Groeneweg, M. ^{[3
]}

Bruggenwirth, H. T. ^{[4
]}

Castelijns, S. J. A. M. ^{[5
]}

van der Ent, C. K. ^{[6
]}

Voorter, C. E. M. ^{[3
]}

Tilanus, M. G. J. ^{[3
]}

机构：

[1] Maastricht Univ, Med Ctr, Dept Paediat, NL-6229 HX Maastricht, Netherlands

[2] Maastricht Univ, Med Ctr, Nutr & Toxicol Res Inst Maastricht NUTRIM, NL-6229 HX Maastricht, Netherlands

[3] Maastricht Univ, Med Ctr, Dept Transplantat Immunol & Tissue Typing, NL-6229 HX Maastricht, Netherlands

[4] Erasmus MC, Dept Clin Genet, DNA Diagnost Lab, Rotterdam, Netherlands

[5] Univ Med Ctr Utrecht, Dept Paediat Gastroenterol, Utrecht, Netherlands

[6] Univ Med Ctr Utrecht, Dept Paediat Pulmonol, Utrecht, Netherlands

来源：

TISSUE ANTIGENS | 2014年 / 83卷 / 01期

关键词：

cystic fibrosis; cystic fibrosis transmembrane conductance regulator; HLA antigens; HLA-DQ alpha-chains; HLA-DQ beta-chains; HLA-DRB1; chains; POPULATION; GUIDELINES; DIAGNOSIS; ALLELES; DISEASE; ADULTS;

D O I：

10.1111/tan.12265

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cystic fibrosis (CF) is classically attributed to the dysfunction of the single CF transmembrane conductance regulator gene. The incidence of human leukocyte antigen (HLA) polymorphisms in different CF-associated diseases raises the question of an unequal distribution of HLA genotypes in CF. This study aimed to evaluate HLA gene frequencies and possible associations in CF patients compared with a control population. Frequencies of HLA-DRB1, HLA-DQA1 and HLA-DQB1, performed by intermediate resolution typing using Luminex sequence-specific oligonucleotide, and epitope counts were similar in 340 CF patients when compared with 400 control subjects. In conclusion, HLA-DRB1, -DQA1 and -DQB1 do not seem to influence susceptibility to CF. Whether HLA plays a role in the severity of CF disease needs to be investigated.

引用

页码：27 / 31

页数：5

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