Uric Acid and Diabetes: Is there a Link?

被引：94

作者：

Katsiki, Niki ^{[1
]}

Papanas, Nikolaos ^{[2
]}

Fonseca, Vivian A. ^{[3
,4
]}

Maltezos, Efstratios ^{[2
]}

Mikhailidis, Dimitri P. ^{[1
]}

机构：

[1] UCL, Sch Med, Dept Clin Biochem Vasc Dis Prevent Clin, London NW3 2QG, England

[2] Democritus Univ Thrace, Dept Internal Med 2, Outpatient Clin Obes Diabet & Metab, Komotini, Greece

[3] Tulane Univ, Hlth Sci Ctr, Dept Med, New Orleans, LA 70112 USA

[4] Tulane Univ, Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA 70112 USA

来源：

CURRENT PHARMACEUTICAL DESIGN | 2013年 / 19卷 / 27期

关键词：

Uric acid; type; 1; diabetes; 2; diabetic complications; drugs; CORONARY-HEART-DISEASE; FATTY LIVER-DISEASE; ISCHEMIC NONEMBOLIC STROKE; IMPAIRED FASTING GLUCOSE; 3RD NATIONAL-HEALTH; METABOLIC SYNDROME; RENAL-FUNCTION; RISK-FACTORS; GREEK ATORVASTATIN; INSULIN-RESISTANCE;

D O I：

10.2174/1381612811319270016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Elevated serum uric acid (SUA) levels (i.e. hyperuricaemia) have been associated with metabolic syndrome (MetS) and cardiovascular disease (CVD) morbidity and mortality. Elevated SUA levels predict the onset of type 2 diabetes (T2DM). SUA levels are increased during the early stages of impaired glucose metabolism. Furthermore, in diabetic patients, hyperuricaemia has been linked to both micro- and macrovascular complications. The present review considers: (1) SUA levels in patients with MetS, type 1 diabetes and T2DM; (2) the mechanisms that influence SUA levels in these patients; (3) the potential links between SUA and diabetic complications. The effect on SUA levels of drugs commonly prescribed for T2DM and the risk of uric acid nephrolithiasis in patients with MetS or DM are also briefly discussed.

引用

页码：4930 / 4937

页数：8

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