A Facile Strategy to Fabricate Polysaccharide-Based Magnetic Hydrogel Based on Enamine Bond

of main observation and conclusion Magnetic hydrogels have found extensive applications in fields such as soft robotics, drug delivery and shape morphing. Here a facile method was fabricated to prepare polysaccharide-based magnetic hydrogels. The chitosan-Fe(3)O(4)ferrofluid was obtained by dispersing carboxyl groups modified Fe(3)O(4)nanoparticles uniformly in chitosan matrix. Subsequently, the magnetic polysaccharide hydrogel was obtained by simply mixing cellulose acetoacetate solution with chitosan-Fe(3)O(4)ferrofluid. The structures and properties of the magnetic hydrogel were analyzed using Fourier-transform infrared spectroscopy, rheological recovery, responsiveness, and stability measurements. The results indicated that magnetic polysaccharide hydrogel showed pH responsiveness and excellent self-healing properties, and the hydrogel manifested outstanding stability under physiological conditions (37 degrees C) for 72 h. In addition, the injectable polysaccharide-based hydrogel exhibited sensitive magnetic responsive and shape-shifting ability under an external magnetic field. Therefore, the strategy for the facile preparation of the magnetic polysaccharide-based hydrogel in this work could provide a benign and versatile method for achieving self-healing, responsive, injectable properties for the application in biomedical fields.