Quantitative 1H NMR spectroscopy

被引：544

作者：

Bharti, Santosh Kumar ^{[1
]}

Roy, Raja ^{[1
]}

机构：

[1] Sanjay Gandhi Post Grad Inst Med Sci Campus, Ctr Biomed Magnet Resonance, Lucknow 226014, Uttar Pradesh, India

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2012年 / 35卷

关键词：

Calibration-curve method; Electronic referencing; Metabolomics; NMR spectroscopy; Nuclear magnetic resonance (NMR); Pharmaceutical analysis; Quantitative NMR (qNMR); Referencing technique; Standard-addition method; Validation; NMR-SPECTROSCOPY; MAGNETIC-RESONANCE; NATURAL-PRODUCTS; BIOLOGICAL-FLUIDS; ERETIC METHOD; SERUM; QUANTIFICATION; MIXTURES; SPECTRA; SIGNAL;

D O I：

10.1016/j.trac.2012.02.007

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This review illustrates the need to use nuclear magnetic resonance (NMR) spectroscopy for the quantitative analysis of small molecules in their crude forms and in mixtures. We provide the basic concepts of quantitative NMR (qNMR), a brief description of important acquisition and processing parameters responsible for obtaining high-quality, reproducible NMR spectra in order to maximize accuracy, and the latest referencing techniques used for quantitative analysis. We also describe methods that are used for quantitative analysis including calibration-curve and standard-addition methods. Further, we briefly address validation of qNMR spectroscopy and its major applications in various scientific disciplines. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：5 / 26

页数：22

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