Determination of phenothiazine derivatives by high performance thin-layer chromatography combined with densitometry

被引：24
|
作者：
Wójciak-Kosior, M
Skalska, A
Matysik, A
机构：
[1] Med Acad, Lab Planar Chromatog, Dept Chem, PL-20081 Lublin, Poland
[2] Med Acad, Clin Ophthalmol 2, PL-20079 Lublin, Poland
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2006年 / 41卷 / 01期
关键词：
HPTLC-densitometry; phenothiazine derivatives; promethazine hydrochloride;
D O I：
10.1016/j.jpba.2005.10.035
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A high performance thin-layer chromatography (HPTLC) method combined with densitometry for determination of phenothiazine derivatives is described. Quantitation was performed in reflectance mode by using a computer-controlled densitometer Desaga CD 60. Established calibration curve (r > 0.999), precision (RDS values: 0.95-2.53%), detection limits as well as recovery values (101.1-102.8%) were found to be satisfactory. The presented method is rapid, precise and sensitive, and may be alternative to traditionally used HPLC. The method has been Successfully applied in the analysis of pharmaceutical formulations. (c) 2005 Elsevier B.V. All rights reserved.
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页码：286 / 289
页数：4
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