Cell panel profiling of pre-clinical and clinical anti-cancer agents reveals conserved therapeutic clusters and differentiates the mechanism of action of different PI3K/mTOR, Aurora kinase and EZH2 inhibitors

被引：0

作者：

Uitdehaag, J. C. M. ^{[1
]}

De Roos, J. A. D. M. ^{[1
]}

Prinsen, M. B. W. ^{[1
]}

Willemsen-Seegers, N. ^{[1
]}

De Vetter, J. R. F. ^{[1
]}

Dylus, J. ^{[1
]}

Van Doornmalen, A. M. ^{[1
]}

Kooijman, J. ^{[1
]}

Sawa, M. ^{[2
]}

Van Gerwen, S. J. C. ^{[1
]}

De Man, J. ^{[3
]}

Buijsman, R. C. ^{[3
]}

Zaman, G. J. R. ^{[1
]}

机构：

[1] Netherlands Translat Res Ctr BV, Dept Biol, Oss, Netherlands

[2] Carna Biosci Inc, Dept Chem, Kobe, Hyogo, Japan

[3] Netherlands Translat Res Ctr BV, Dept Chem, Oss, Netherlands

来源：

EUROPEAN JOURNAL OF CANCER | 2016年 / 69卷

关键词：

D O I：

10.1016/S0959-8049(16)32652-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：S24 / S24

页数：1

共 4 条

[1] Cell Panel Profiling Reveals Conserved Therapeutic Clusters and Differentiates the Mechanism of Action of Different PI3K/mTOR, Aurora Kinase and EZH2 Inhibitors
Uitdehaag, Joost C. M.
de Roos, Jeroen A. D. M.
Prinsen, Martine B. W.
Willemsen-Seegers, Nicole
de Vetter, Judith R. F.
Dylus, Jelle
van Doornmalen, Antoon M.
Kooijman, Jeffrey
Sawa, Masaaki
van Gerwen, Suzanne J. C.
de Man, Jos
Buijsman, Rogier C.
Zaman, Guido J. R.
MOLECULAR CANCER THERAPEUTICS, 2016, 15 (12) : 3097 - 3109
[2] Comparative cancer cell line profiling differentiates the mechanism of action of different PI3K/mTOR, Aurora kinase and EZH2 inhibitors
Uitdehaag, Joost C. M.
de Roos, Jeroen A. D. M.
Prinsen, Martine B. W.
de Vetter, Judith R. F.
Dylus, Jelle
van Doornmalen, Antoon M.
van Gerwen, Suzanne J. C.
de Man, Jos
Buijsman, Rogier C.
Zaman, Guido J. R.
CANCER RESEARCH, 2016, 76
[3] Mechanistic differentiation of PI3K/mTOR, Aurora kinase and EZH2 inhibitor classes by comparative cancer cell line profiling
Uitdehaag, J. C. M.
De Roos, J. A. D. M.
Prinsen, M. B. W.
De Vetter, J. R. F.
Dylus, J.
Van Doornmalen, A. M.
Van Gerwen, S. J. C.
De Man, J.
Buijsman, R. C.
Zaman, G. J. R.
EUROPEAN JOURNAL OF CANCER, 2016, 61 : S127 - S127
[4] Pre-clinical activity and mechanism of action of the novel dual PI3K/mTOR inhibitor PQR309 in B-cell lymphomas
Tarantelli, Chiara
Gaudio, Eugenio
Kwee, Ivo
Rinaldi, Andrea
Bernasconi, Elena
Cascione, Luciano
Hillmann, Petra
Stathis, Anastasios
Carrassa, Laura
Broggini, Massimo
Stussi, Georg
Fabbro, Doriano
Beaufils, Florent
Melone, Anna
Bohnacker, Thomas
Wymann, Matthias P.
Wicki, Andreas
Zucca, Emanuele
Cmiljanovic, Vladimir
Bertoni, Francesco
CANCER RESEARCH, 2015, 75

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