Attrition in the drug discovery process: lessons to be learned from the safety pharmacology paradigm

被引：0
|
作者：
Curtis, Michael J. [1 ]
Pugsley, Michael K. [2 ]
机构：
[1] St Thomas Hosp, Kings Coll London, Rayne Inst, Div Cardiovasc, London SE1 7EH, England
[2] Janssen Res & Dev, Dept Toxicol & Pathol Drug Safety Sci, Raritan, NJ 08869 USA
来源：
EXPERT REVIEW OF CLINICAL PHARMACOLOGY | 2012年 / 5卷 / 03期
关键词：
academia; cardiac toxicity; discovery pharmacology; drug attrition; drug development costs; intellectual property; safety pharmacology; INNOVATION;
D O I：
10.1586/ECP.12.22
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：237 / 240
页数：4
相关论文
共 50 条
  • [1] Lessons learned from candidate drug attrition
    Empfield, James R.
    Leeson, Paul D.
    IDRUGS, 2010, 13 (12) : 869 - 873
  • [2] Lessons learned from phenotypic drug discovery efforts
    Swinney, David C.
    EXPERT OPINION ON DRUG DISCOVERY, 2025, 20 (02) : 141 - 144
  • [3] Early safety assessment strategies for drug discovery at Celgene and lessons learned
    Piccotti, Joseph
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258
  • [4] Lessons learned in TB drug discovery
    Jiricek, Jan
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 247
  • [5] Network pharmacology: the next paradigm in drug discovery
    Hopkins, Andrew L.
    NATURE CHEMICAL BIOLOGY, 2008, 4 (11) : 682 - 690
  • [6] Constellation Pharmacology: A New Paradigm for Drug Discovery
    Teichert, Russell W.
    Schmidt, Eric W.
    Olivera, Baldomero M.
    ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55, 2015, 55 : 573 - 589
  • [7] Modular pharmacology: the next paradigm in drug discovery
    Wang, Zhong
    Liu, Jun
    Yu, Yanan
    Chen, Yinying
    Wang, Yongyan
    EXPERT OPINION ON DRUG DISCOVERY, 2012, 7 (08) : 667 - 677
  • [8] Network pharmacology: the next paradigm in drug discovery
    Andrew L Hopkins
    Nature Chemical Biology, 2008, 4 : 682 - 690
  • [9] Lessons Learned from Recent Process Safety Incidents
    Ness, Albert
    CHEMICAL ENGINEERING PROGRESS, 2015, 111 (03) : 23 - 29
  • [10] From plant to cancer drug: lessons learned from the discovery of taxol
    Cech, Nadja B. B.
    Oberlies, Nicholas H. H.
    NATURAL PRODUCT REPORTS, 2023, 40 (07) : 1153 - 1157
12345