IL-1 receptor type I expression in breast cancer

被引：3
|
作者：
Knüpfer, H
Stanitz, D
Brauckhoff, M
Schmidt, R
Knüpfer, MM
Preiss, R
机构：
[1] Paul Flechsig Inst Brain Res, Abt Neuroanat, D-04109 Leipzig, Germany
[2] Univ Leipzig, Inst Klin Pharmakol, D-04107 Leipzig, Germany
[3] Univ Halle Wittenberg, Klin & Poliklin Allgemeinchirurg, Halle An Der Saale, Germany
[4] Univ Leipzig, Kinderklin, KIK B, D-04103 Leipzig, Germany
来源：
BREAST | 2001年 / 10卷 / 05期
关键词：
D O I：
10.1054/brst.2000.0269
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The cytokine interleukin (IL)-1 is known to be involved in angiogenesis and metastasis. A prerequisite for IL-1 signalling is the presence of its receptor. Previously we have shown that glioblastoma cells express the IL-1 receptor type I (IL-1RI). In this study we analysed I I breast tumour specimens for IL-1RI expression using the reverse transcriptase (RT) polymerase chain reaction (PCR). We found all the I I breast tumours were positive for IL-1RI. This suggests that paracrine or autocrine produced IL-1 mediated signalling via IL-IRI might take place in breast tumours to control the production of pro-tumourigenic factors such as angiogenic factors and support further progression of tumour growth and metastasis. (C) 2001 Harcourt Publishers Ltd.
引用
收藏
页码：411 / 415
页数：5
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