IL-36 RECEPTOR ANTAGONIST WITH SPECIAL EMPHASIS ON IL-38

被引：20

作者：

Shaik, Y. ^{[1
]}

Sabatino, G. ^{[2
]}

Maccauro, G. ^{[3
]}

Varvara, G. ^{[4
]}

Murmura, G. ^{[4
]}

Saggini, A. ^{[5
]}

Rosati, M. ^{[6
]}

Conti, F. ^{[6
]}

Cianchetti, E. ^{[7
]}

Caraffa, A. ^{[8
]}

Antinolfi, P. ^{[8
]}

Pandolfi, F. ^{[9
]}

Potalivo, G. ^{[8
]}

Galzio, R. ^{[10
]}

Conti, P. ^{[11
]}

Theoharides, T. C. ^{[12
]}

机构：

[1] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

[2] Univ G dAnnunzio, Div Neonatol, Chieti, Italy

[3] Univ Cattolica Sacro Cuore, Dept Orthoped, Rome, Italy

[4] Univ G dAnnunzio, Sch Dent, Chieti, Italy

[5] Univ Roma Tor Vergata, Dept Dermatol, Rome, Italy

[6] Osped Pescara, Gynecol Div, Pescara, Italy

[7] Univ G dAnnunzio, Ortona Hosp, Chieti, Italy

[8] Univ Perugia, Orthopead Div, I-06100 Perugia, Italy

[9] Univ Cattolica Sacro Cuore, Dept Internal Med, I-00168 Rome, Italy

[10] Univ Aquila, Dept Hlth Sci, I-67100 Laquila, Italy

[11] Univ G dAnnunzio, Dept Expt & Clin Sci, Div Immunol, Chieti, Italy

[12] Tufts Univ, Sch Med, Tufts New England Med Ctr, Dept Pharmacol & Expt Therapeut Biochem & Interna, Boston, MA 02111 USA

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2013年 / 26卷 / 01期

关键词：

IL-36; IL-38; cytokines; inflammation; immunity; NF-KAPPA-B; IN-VITRO; GENE-EXPRESSION; GROWTH-FACTOR; MAST-CELLS; MATRIX METALLOPROTEINASES; BIOACTIVE COMPOUND; PERIPHERAL-BLOOD; T-CELLS; ALPHA;

D O I：

10.1177/039463201302600103

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-36 is another family member of IL-1 and induces the production of proinflammatory cytokines and activates MAPK and NF kappa B pathways. IL-36 is a common mediator of innate and adaptive immune response and is inhibited by IL-36 receptor antagonist (RA). IL-36RA acts on IL-36 receptor ligand which exerts proinflammatory effect in vivo and in vitro. IL-38 binds to IL-36 receptor as does IL-36RA and has similar biological effects on immune cells. IL-38 is also a member of IL-1 cytokine and shares some characteristics of IL-1RA, binding the same IL-1 receptor type I. IL-38 plays a role in the pathogenesis of inflammatory diseases, exerting protective effect in some autoimmune diseases. Both IL-38 and IL-36RA have an anti-inflammatory biological effect, however in some cases have contrary effects.

引用

页码：27 / 36

页数：10

共 50 条

[1] IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist
van de Veerdonk, Frank L.
Stoeckman, Angela K.
Wu, Gouping
Boeckermann, Aaron N.
Azam, Tania
Netea, Mihai G.
Joosten, Leo A. B.
van der Meer, Jos W. M.
Hao, Ruyi
Kalabokis, Vassili
Dinarello, Charles A.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (08) : 3001 - 3005
[2] The complex roles of IL-36 and IL-38 in cancer: friends or foes?
Méabh Finucane
Elizabeth Brint
Aileen Houston
Oncogene, 2025, 44 (13) : 851 - 861
[3] IL-34, IL-36 and IL-38 in colorectal cancer—key immunoregulators of carcinogenesis
Bao S.
Hu R.
Hambly B.D.
Biophysical Reviews, 2020, 12 (4) : 925 - 930
[4] The Emerging Roles of IL-36, IL-37, and IL-38 in Diabetes Mellitus and its Complications
Huang, Guoqing
Li, Mingcai
Tian, Xiaoqing
Jin, Qiankai
Mao, Yushan
Li, Yan
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, 2022, 22 (10) : 997 - 1008
[5] Expression of IL-36 family cytokines and IL-37 but not IL-38 is altered in psoriatic skin
Keermann, Maris
Koks, Sulev
Reimann, Ene
Abram, Kristi
Erm, Triin
Silm, Helgi
Kingo, Kuelli
JOURNAL OF DERMATOLOGICAL SCIENCE, 2015, 80 (02) : 150 - 152
[6] Interleukin-36 (IL-36) Ligands Require Processing for Full Agonist (IL-36α, IL-36β, and IL-36γ) or Antagonist (IL-36Ra) Activity
Towne, Jennifer E.
Renshaw, Blair R.
Douangpanya, Jason
Lipsky, Brian P.
Shen, Min
Gabel, Christopher A.
Sims, John E.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (49) : 42594 - 42602
[7] Roles of novel IL-1 family (IL-36, IL-37, and IL-38) members in chronic brucellosis
Hiz, Pinar
Kanbur, Ertan
Demir, Nesrin
Akalin, Halis
Cagan, Eren
Pashazadeh, Mehrdat
Bal, Salih Haldun
Tezcan, Gulcin
Oral, Haluk Barbaros
Budak, Ferah
CYTOKINE, 2020, 135
[8] IL-38 and IL-36 Target Autophagy for Regulating Synoviocyte Proliferation, Migration, and Invasion in Rheumatoid Arthritis
Hao, Zhe
Liu, Yi
DISEASE MARKERS, 2021, 2021
[9] IL-38 alleviates airway remodeling in chronic asthma via blocking the profibrotic effect of IL-36γ
Zhang, Min
Zhou, Jian-Xia
Huang, Chu-Qin
Feng, Kang-Ni
Zou, Xiao-Ling
Cen, Jie-Mei
Meng, Ping
Li, Hong-Tao
Zhang, Tian-Tuo
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2023, 214 (03): : 260 - 274
[10] IL-36, IL-37, and IL-38 Cytokines in Skin and Joint Inflammation: A Comprehensive Review of Their Therapeutic Potential
Boutet, Marie-Astrid
Nerviani, Alessandra
Pitzalis, Costantino
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (06)

← 1 2 3 4 5 →