Synthesis and Antimicrobial Activity of 2-(Pyridine-3-yl)-4H-chromen-4-one Derivatives

An efficiently synthesis of chromones via cyclodehydration of corresponding 1-(2-hydroxyphenyl)-3-(pyridine-3-yl)propane-1,3-dione is described under ultrasound irradiation. A series of novel 2-(pyridine-3-yl)-4H-chromen-4-one derivatives was confirmed on the basis of 1H-NMR, mass, IR spectral data, and elemental analysis. The synthesized compounds were evaluated for their antibacterial and antifungal activities. Most of the compounds were found to be comparable potent than the reference standard drugs. Utilization of ultrasound irradiation, simple reaction conditions, isolation, and purification makes this manipulation very interesting from an economic and environmental perspective.