Optical detection of DNA hybridization using absorption spectra of single-walled carbon nanotubes

被引：25

作者：

Cao, Chengfan ^{[1
]}

Kim, Jung Heon ^{[2
]}

Yoon, Dokyung ^{[3
]}

Hwang, Eung-Soo ^{[2
]}

Kim, Young-Jin ^{[1
,3
]}

Baik, Seunghyun ^{[1
,3
]}

机构：

[1] Sungkyunkwan Univ, Sch Mech Engn, Suwon 440746, Kyeonggi, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul 110799, South Korea

[3] Sungkyunkwan Univ, SKKU Adv Inst Nanotechnol SAINT, Suwon 440746, Kyeonggi, South Korea

来源：

MATERIALS CHEMISTRY AND PHYSICS | 2008年 / 112卷 / 03期

关键词：

Single-walled carbon nanotubes; Optical nano-biosensor; Absorption; DNA hybridization; Oligonucleotide;

D O I：

10.1016/j.matchemphys.2008.07.129

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Single-walled carbon nanotubes (SWCNTs) exhibit sharp absorption peak distributions in the UV-vis-nIR range when they are individually dispersed in aqueous solution medium. In this paper, we developed SWCNT-based molecular probes by conjugating single-stranded DNA (ssDNA) with SWCNT. The DNA hybridization event was investigated using the absorption spectra of the ssDNA-SWCNT probes. The results showed that DNA hybridization on the sidewall of SWCNT resulted in systematic red shifts of the absorption spectra of semiconducting nanotubes. However, metallic species did not show any shift in the absorption spectra. The work demonstrated that ssDNA-SWCNTs probes might be used to detect specific kinds of DNA oligonucleotides as optical nano-biosensors. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：738 / 741

页数：4

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