Mass spectrometric analysis of head-to-tail connected cyclic peptides

被引：0

作者：

Macht, M ^{[1
]}

Pelzing, M ^{[1
]}

Palloch, P ^{[1
]}

Sauerland, V ^{[1
]}

Volz, J ^{[1
]}

机构：

[1] Bruker Saxonia Analyt GmbH, Leipzig, Germany

来源：

ACTA BIOCHIMICA POLONICA | 2001年 / 48卷 / 04期

关键词：

mass spectrometry; peptide sequencing; post source decay; electrospray; MALDI;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tandem mass spectrometry is an extremly useful tool for high sensitive sequence identification of peptides. In the case of cyclic peptides fragmentation can easily be performed for sequence analysis. However, analysis is usually tedious due to the lack of a defined beginning and end of the sequence. Since cyclic peptides are a highly interesting class of compounds especially for the pharmaceutical industry, ways have to be found to identify their structures. In this work we demonstrate how software and dedicated analytical strategies can be used for detailed analysis of these substances.

引用

页码：1109 / 1112

页数：4

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