The Role of Gluten in Celiac Disease and Type 1 Diabetes

被引：47

作者：

Serena, Gloria ^{[1
,2
,3
]}

Camhi, Stephanie ^{[1
,2
]}

Sturgeon, Craig ^{[1
,2
,3
]}

Yan, Shu ^{[1
,2
]}

Fasano, Alessio ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Celiac Res, Mucosal Immunol & Biol Res Ctr, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp Children, Div Pediat Gastroenterol & Nutr, Boston, MA 02114 USA

[3] Univ Maryland, Sch Med, Grad Program Life Sci, Baltimore, MD 21201 USA

来源：

NUTRIENTS | 2015年 / 7卷 / 09期

关键词：

celiac disease; type; 1; diabetes; gluten; INTESTINAL PERMEABILITY; ISLET AUTOIMMUNITY; TISSUE TRANSGLUTAMINASE; ENTEROVIRUS INFECTIONS; MICROBIOTA COMPOSITION; TYROSINE PHOSPHATASE; DIETARY INTERVENTION; IMMUNE-RESPONSE; WHEAT GLUTEN; RISK-FACTORS;

D O I：

10.3390/nu7095329

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Celiac disease (CD) and type 1 diabetes (T1D) are autoimmune conditions in which dietary gluten has been proven or suggested to play a pathogenic role. In CD; gluten is established as the instigator of autoimmunity; the autoimmune process is halted by removing gluten from the diet; which allows for resolution of celiac autoimmune enteropathy and subsequent normalization of serological markers of the disease. However; an analogous causative agent has not yet been identified for T1D. Nevertheless; the role of dietary gluten in development of T1D and the potentially beneficial effect of removing gluten from the diet of patients with T1D are still debated. In this review; we discuss the comorbid occurrence of CD and T1D and explore current evidences for the specific role of gluten in both conditions; specifically focusing on current evidence on the effect of gluten on the immune system and the gut microbiota.

引用

页码：7143 / 7162

页数：20

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