Chiral pH-Responsive Amphiphilic Polymer Co-networks: Preparation, Chiral Recognition, and Release Abilities

被引:15
|
作者
Shi, Lu [1 ]
Xie, Peng [1 ]
Li, Zhimin [1 ]
Wu, Youping [1 ]
Deng, Jianping [2 ]
机构
[1] Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Coll Mat Sci & Engn, Beijing 100029, Peoples R China
[2] Beijing Univ Chem Technol, State Key Lab Chem Resource Engn, Coll Mat Sci & Engn, Beijing 100029, Peoples R China
基金
中国国家自然科学基金;
关键词
adsorption; amphiphilic co-networks; chiral; enantioselective release; pH-responsiveness; SOLID-STATE NMR; SWELLING BEHAVIOR; RAFT POLYMERIZATION; MODEL CONETWORKS; ORGANIC-SOLVENTS; METHACRYLIC-ACID; COPOLYMERS; GELS; MICROSPHERES; SPECTROSCOPY;
D O I
10.1002/macp.201200729
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Novel amphiphilic polymer co-networks (APCNs), poly(N-acryloyl-L-alanine)-l-polydimethylsiloxane (denoted as PNAA-l-PDMS), are prepared, and exhibit remarkable pH-responsiveness, chiral-recognition, and enantioselective-release abilities. The APCNs are prepared by free-radical copolymerization starting from N-acryloyl-L-alanine (NAA) and methacrylate-terminated poly(dimethylsiloxane) (M-PDMS) as co-(macro)monomers. The APCNs show pronounced pH-sensitivity, evidenced by a reversible swelling-deswelling transition upon a cyclicly altering pH. The chiral co-networks are applied for enantioselective recognition and release. A maximum adsorption is achieved towards D-proline (61%), whereas for L-proline, it is only 10%. More interestingly, the release for the L-proline is 90%, whereas for the D-proline, only 70% is released.
引用
收藏
页码:1375 / 1383
页数:9
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