GENOTYPIC RESISTANCE PROFILE OF HIV-1 PROTEASE GENE: A PRELIMINARY REPORT FROM VELLORE, SOUTH INDIA

被引：0
|
作者：
Kandathil, A. J. [1 ]
Kannangai, R. [1 ]
Abraham, O. C. [2 ]
Sudarsanam, T. D. [2 ]
Pulimood, S. A. [3 ]
Sridharan, G. [1 ]
机构：
[1] Christian Med Coll & Hosp, Dept Clin Virol, Vellore 632004, Tamil Nadu, India
[2] Christian Med Coll & Hosp, Dept Internal Med, Vellore 632004, Tamil Nadu, India
[3] Christian Med Coll & Hosp, Dept Dermatol, Vellore 632004, Tamil Nadu, India
来源：
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY | 2008年 / 26卷 / 02期
关键词：
Drug resistance; India; HIV-1; protease gene mutations;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
HIV-1 subtypes other than B are responsible for most new HIV infections worldwide; virus sequence data for drug resistance is described only from a limited number of non-B subtype HIV-1. This study is on mutations and polymorphisms of HIV-1 protease gene that can predict drug resistance in subtype C. The genotypic resistance assay was carried out on 38 HIV-1 strains with their plasma RNA and in nine, the proviral protease gene was sequenced. The treatment nave strains showed minor resistance mutations, there were no major resistance mutations in the protease gene. We suggest the use of resistance testing to monitor individuals on therapy and also before initiation of therapy, gathering more sequence information for a data bank of Indian strains.
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页码：151 / 154
页数：4
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