Is there a Benefit of Adding Conservative Treatment Modalities on Trospium Chloride Treatment in Overactive Bladder Syndrome

Objective: To evaluate whether conservative treatment modalities of overactive bladder syndrome combined with trospium chloride increases the success rate when compared with trospium chloride alone Design: Retrospective study Setting: Department of Obstetrics and Gynecology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey Subjects: The data of 3200 patients, who were admitted with complaint of urinary incontinence, were analyzed and 270 patients treated with trospium chloride were included. Thirty-five patients were treated only with trospium chloride; 14 who continued medical treatment for at least six months were classified as Group 1. 235 patients were treated with trospium chloride in combination with other modalities; 126 who continued medical treatment for at least six months were classified as Group 2. Intervention: Treatment with trospium chloride alone or with other modalities. Main Outcome Measures: The 3-day bladder diaries of the two groups were compared before treatment and three and six months after treatment. Results: There was a statistically significant decrease in the mean number of diurnal micturition and incontinence episodes in Group 1 before and after treatment (p = 0.017 and 0.02 respectively). In Group 2, there was a statistically significant decrease in the mean number of urgency, urinary incontinence episodes, diurnal, and nocturnal micturition (p < 0.001, < 0.001, < 0.001 and 0.002 respectively). We found no statistically significant difference between the two groups after the treatment. Conclusions: Addition of conservative treatment modalities to trospium chloride in overactive bladder did not lead to a significant difference in results.