No association between iron status and self-reported health-related quality of life in 16,375 Danish blood donors: results from the Danish Blood Donor Study
BACKGROUNDHealth-related quality of life (HRQL) represents people's subjective assessment of their mental and physical well-being. HRQL is highly predictive of future health. The effect of iron deficiency without anemia induced by blood donation on HRQL is presently unknown. The aim was to explore the relationship between iron status and self-reported mental component score (MCS; SF-12) and physical component score (PCS; SF-12) in Danish blood donors. STUDY DESIGN AND METHODSComplete relevant data, including the 12-item short-form health survey (SF-12), plasma ferritin levels, age, body mass index, smoking status, C-reactive protein levels, number of donations in the previous 3 years, and PCS and MCS, were available for 8692 men and 7683 women enrolled from March 1, 2010, to December 31, 2010. Multivariable linear and logistic (cutoff at the 10th percentile) regression analyses were used to assess the relationship between iron deficiency (ferritin<15 ng/mL) and MCS and PCS, respectively. Analyses were performed separately for men and women. RESULTSThere was no significant relationship between iron deficiency and self-reported mental or physical health. CONCLUSIONThis study found no association between iron stores and self-reported HRQL among Danish blood donors.
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Department of Pharmacy, National University of Singapore, SingaporeDepartment of Pharmacy, National University of Singapore, Singapore
Gan H.P.
Wee H.L.
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Department of Pharmacy, National University of Singapore, Singapore
Department of Rheumatology and Immunology, Singapore General Hospital, Outram RoadDepartment of Pharmacy, National University of Singapore, Singapore
Wee H.L.
Cheung Y.B.
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机构:
Singapore Clinical Research Institute, Singapore
Duke-NUS Graduate Medical School, Singapore
Department of International Health, University of Tampere, TampereDepartment of Pharmacy, National University of Singapore, Singapore
Cheung Y.B.
Luo N.
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Saw Swee Hock School of Public Health, National University of Singapore, Singapore
Centre for Health Services Research, National University of Singapore, SingaporeDepartment of Pharmacy, National University of Singapore, Singapore
Luo N.
Fong K.Y.
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Department of Rheumatology and Immunology, Singapore General Hospital, Outram Road
Duke-NUS Graduate Medical School, Singapore
Yong Loo Lin School of Medicine, National University of Singapore, SingaporeDepartment of Pharmacy, National University of Singapore, Singapore
Fong K.Y.
Feeny D.
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Center for Health Research, Kaiser Permanente North-west Region, Portland, OR
Health Utilities Incorporated, Dundas, ONDepartment of Pharmacy, National University of Singapore, Singapore
Feeny D.
Thumboo J.
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机构:
Department of Rheumatology and Immunology, Singapore General Hospital, Outram Road
Duke-NUS Graduate Medical School, Singapore
Yong Loo Lin School of Medicine, National University of Singapore, SingaporeDepartment of Pharmacy, National University of Singapore, Singapore