Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: A nested case-control study

被引：43

作者：

Kuehn, Tilman ^{[1
]}

Kaaks, Rudolf ^{[1
]}

Becker, Susen ^{[1
,2
]}

Eomois, Piia-Piret ^{[1
]}

Clavel-Chapelon, Francoise ^{[3
,4
]}

Kvaskoff, Marina ^{[3
,4
]}

Dossus, Laure ^{[3
,4
]}

Tjonneland, Anne ^{[5
]}

Olsen, Anja ^{[5
]}

Overvad, Kim ^{[6
]}

Chang-Claude, Jenny ^{[1
]}

Lukanova, Annekatrin ^{[1
]}

Buijsse, Brian ^{[7
]}

Boeing, Heiner ^{[7
]}

Trichopoulou, Antonia ^{[8
,9
]}

Lagiou, Pagona ^{[8
,10
]}

Bamia, Christina ^{[8
]}

Masala, Giovanna ^{[11
]}

Krogh, Vittorio ^{[12
]}

Sacerdote, Carlotta ^{[13
,14
]}

Tumino, Rosario ^{[15
]}

Mattiello, Amalia ^{[16
]}

Buckland, Genevieve ^{[17
]}

Sanchez, Maria-Jose ^{[18
,19
]}

Menendez, Virginia ^{[20
]}

Chirlaque, Maria-Dolores ^{[19
,21
]}

Barricarte, Aurelio ^{[19
,22
]}

Bueno-de-Mesquita, H. Bas ^{[23
,24
]}

van Duijnhoven, Fraenzel J. B. ^{[23
,25
]}

van Gils, Carla H. ^{[26
]}

Bakker, Marije F. ^{[26
]}

Weiderpass, Elisabete ^{[27
,28
,29
,30
]}

Skeie, Guri ^{[27
]}

Brustad, Magritt ^{[27
]}

Andersson, Anne ^{[31
]}

Sund, Malin ^{[32
]}

Wareham, Nick ^{[33
]}

Khaw, Kay Tee ^{[34
]}

Travis, Ruth C. ^{[35
]}

Schmidt, Julie A. ^{[35
]}

Rinaldi, Sabina ^{[36
]}

Romieu, Isabelle ^{[36
]}

Gallo, Valentina ^{[37
,38
]}

Murphy, Neil ^{[37
]}

Riboli, Elio ^{[37
]}

Linseisen, Jakob ^{[1
,39
]}

机构：

[1] German Canc Res Ctr DKFZ Heidelberg, Div Canc Epidemiol, D-69120 Heidelberg, Germany

[2] Univ Hosp Leipzig, Inst Lab Med, Leipzig, Germany

[3] Inst Gustave Roussy, INSERM, Ctr Res Epidemiol & Populat Hlth, U1018, F-94805 Villejuif, France

[4] Paris South Univ, UMRS 1018, Villejuif, France

[5] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[6] Aarhus Univ, Dept Publ Hlth, Epidemiol Sect, Aarhus, Denmark

[7] German Inst Human Nutr DIfE Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany

[8] Univ Athens Med Sch, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, Athens, Greece

[9] Hellen Hlth Fdn, Athens, Greece

[10] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[11] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[12] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[13] Ctr Canc Prevent CPO Piemonte, Turin, Italy

[14] Human Genet Fdn HuGeF, Turin, Italy

[15] Civile MP Arezzo Hosp ASP, Canc Registry & Histopathol Unit, Ragusa, Italy

[16] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Naples, Italy

[17] Catalan Inst Oncol ICO IDIBELL, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain

[18] Andalusian Sch Publ Hlth, Granada, Spain

[19] CIBERESP, Madrid, Spain

[20] Publ Hlth Directorate Asturias, Oviedo, Spain

[21] Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[22] Publ Hlth Inst Navarra, Pamplona, Spain

[23] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[24] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[25] Wageningen Univ, Div Human Nutr, NL-6700 AP Wageningen, Netherlands

[26] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[27] Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[28] Canc Registry Norway, Oslo, Norway

[29] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[30] Samfundet Folkhalsan, Helsinki, Finland

[31] Umea Univ, Dept Radiat Sci, Umea, Sweden

[32] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden

[33] Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England

[34] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[35] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[36] Int Agcy Res Canc, Nutr & Metab Sect, F-69372 Lyon, France

[37] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

[38] Univ London, Barts & London Sch Med, Ctr Primary Care & Publ Hlth, London, England

[39] German Res Ctr Environm Hlth HMGU, Helmholtz Zentrum Munchen, Inst Epidemiol 1, Neuherberg, Germany

来源：

INTERNATIONAL JOURNAL OF CANCER | 2013年 / 133卷 / 07期

基金：

欧洲研究理事会; 英国医学研究理事会;

关键词：

vitamin D; breast cancer; 25-hydroxyvitamin D; prospective study; estrogen receptor status; D-BINDING PROTEIN; CIRCULATING VITAMIN-D; POSTMENOPAUSAL WOMEN; SERUM-LEVELS; ASSOCIATION; PREVENTION; CALCIUM; REPRODUCIBILITY; PREMENOPAUSAL; METABOLITES;

D O I：

10.1002/ijc.28172

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Experimental evidence suggests that vitamin D might play a role in the development of breast cancer. Although the results of case-control studies indicate that circulating 25-hydroxyvitamin D [25(OH)D] is inversely associated with the risk of breast cancer, the results of prospective studies are inconsistent. A case-control study embedded in the European Prospective Investigation into Cancer and Nutrition (EPIC) was carried out comprising 1,391 incident breast cancer cases and 1,391 controls. Multivariable conditional logistic regression models did not reveal a significant overall association between season-standardized 25(OH)D levels and the risk of breast cancer (ORQ4-Q1 [95% CI]: 1.07 [0.85-1.36], p(trend) = 0.67). Moreover, 25(OH)D levels were not related to the risks of estrogen receptor positive tumors (ORQ4-Q1 [95% CI]: 0.97 [0.67-1.38], p(trend) = 0.90) and estrogen receptor negative tumors (ORQ4-Q1 [95% CI]: 0.97 [0.66-1.42], p(trend) = 0.98). In hormone replacement therapy (HRT) users, 25(OH)D was significantly inversely associated with incident breast cancer (ORlog2 [95% CI]: 0.62 [0.42-0.90], p = 0.01), whereas no significant association was found in HRT nonusers (ORlog2 [95% CI]: 1.14 [0.80-1.62], p = 0.48). Further, a nonsignificant inverse association was found in women with body mass indices (BMI) < 25 kg/m(2) (ORlog2 [95% CI]: 0.83 [0.67-1.03], p = 0.09), as opposed to a borderline significant positive association in women with BMI 25 kg/m(2) (ORlog2 [95% CI]: 1.30 [1.0-1.69], p = 0.05). Overall, prediagnostic levels of circulating 25(OH)D were not related to the risk of breast cancer in the EPIC study. This result is in line with findings in the majority of prospective studies and does not support a role of vitamin D in the development of breast cancer. What's new? Experimental studies have indicated that vitamin D may play a role in preventing tumor formation in the breast. However, in the present investigation, the largest prospective case-control study on circulating 25-hydroxyvitamin D (25(OH)D) and breast cancer risk conducted to date, pre-diagnostic levels of 25(OH)D were found to be unrelated to overall breast cancer risk. While the results support those of similar prospective studies, a significant inverse association was detected between 25(OH)D levels and incident breast cancer in women taking hormone replacement therapy, suggesting that background factors may influence risk associations.

引用

页码：1689 / 1700

页数：12

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