Extended depth-of-field all-optical photoacoustic microscopy with a dual non-diffracting Bessel beam

被引：28
|
作者：
Hu, Yicheng [1 ,2 ,3 ]
Chen, Zhongjiang [1 ,2 ,3 ]
Xiang, Liangzhong [4 ]
Xing, Da [1 ,2 ,3 ]
机构：
[1] South China Normal Univ, MOE Key Lab Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China
[2] South China Normal Univ, Inst Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China
[3] South China Normal Univ, Coll Biophoton, Guangzhou 510631, Guangdong, Peoples R China
[4] Univ Oklahoma, Sch Elect & Comp Engn, Norman, OK 73019 USA
来源：
OPTICS LETTERS | 2019年 / 44卷 / 07期
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
RESOLUTION; INTERFEROMETER; SENSOR;
D O I：
10.1364/OL.44.001634
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
All-optical photoacoustic microscopy (AOPAM) facilitates high-sensitivity, wide-bandwidth, volumetric imaging without coupling media. However, the rapid divergence of the Gaussian beam restricts the stability and depth-of-field in typical Gaussian AOPAM (G-AOPAM). Here we report an extended depth-of-field AOPAM using a dual non-diffracting Bessel beam (B-AOPAM). Benefiting from the designing, the B-AOPAM has the unique advantages of increasing depth resolving ability and improving photoacoustic detection sensitivity. The proposed scheme shows optimal lateral resolution of 2.4 mu m and a long depth-offocus of 635 pm, which is 10-fold larger than that of the G-AOPAM. The scattering phantoms and in vivo animal experiments demonstrated the imaging feasibility and capability of the B-AOPAM, which can provide noncontact, high spatial resolution imaging of non-flat tissue and contribute to future clinical applications. (C) 2019 Optical Society of America
引用
收藏
页码：1634 / 1637
页数：4
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