A Multicomponent, Catalyst-free, One-Pot Synthesis of Functionalized 1,4-Dihydroquinolines and Their Antimicrobial Studies

被引：10

作者：

Chidurala, Praveen ^{[1
]}

Jetti, Venkateshwarlu ^{[1
]}

Pagadala, Ramakanth ^{[2
]}

Meshram, Jyotsna S. ^{[1
]}

Jonnalagadda, Sreekantha B. ^{[2
]}

机构：

[1] Nagpur Univ, Rashtrasant Tukadoji Maharaj, Dept Chem, Civil Lines, Nagpur 440033, Maharashtra, India

[2] Univ KwaZulu Natal, Sch Chem & Phys, ZA-4000 Durban, South Africa

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2015年 / 52卷 / 05期

关键词：

multi-component reaction; microwave method; classical method; 1; 4-dihydro quinolines; POLYHYDROQUINOLINE DERIVATIVES; CYCLIZATION REACTIONS; HANTZSCH REACTION; CASCADE REACTIONS; QUINOLINE; QUINAZOLINE; CHEMISTRY;

D O I：

10.1002/jhet.2230

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An atom-efficient, catalyst-free, and environmentally friendly approach towards the synthesis of substituted 1,4-dihydroquinolines (5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j) through a one-pot multicomponent reaction involving resorcinol, aromatic aldehyde, acetoacetanilide, and ammonium acetate has been developed. The reactions were carried out under both conventional and microwave irradiation conditions. In general, improvement in rate and yield were observed when reactions were carried out under microwave irradiation compared with classical conditions. Most of the new compounds possessed moderate to significant antibacterial and antifungal activities.

引用

页码：1302 / 1307

页数：6

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