Moxifloxacin and azithromycin but not amoxicillin protect human respiratory epithelial cells against Streptococcus pneumoniae in vitro when administered up to 6 hours after challenge

被引：6

作者：

Ulrich, M

Albers, C

Möller, JG

Dalhoff, A

Korfmann, G

Künkele, F

Döring, G

机构：

[1] Univ Klinikum Tubingen, Inst Med Microbiol & Hyg, D-72074 Tubingen, Germany

[2] Bayer Healthcare, Wuppertal, Germany

[3] Bayer Vital GmbH, Leverkusen, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 12期

关键词：

D O I：

10.1128/AAC.49.12.5119-5122.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We determined the protective effect of moxifloxacin, azithromycin, and amoxicillin against Streptococcus pneumoniae infection of respiratory cells. Moxifloxacin and azithromycin effectively killed intracellular S. pneumoniae strains and protected respiratory epithelial cells significantly even when given 6 h after S. pneumoniae challenge. Amoxicillin was less effective.

引用

页码：5119 / 5122

页数：4

共 3 条

[1] Moxifloxacin and Ciprofloxacin Protect Human Respiratory Epithelial Cells against Streptococcus pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, and Haemophilus influenzae in Vitro
M. Ulrich
J. Berger
J.-G. Möller
G. Döring
Infection, 2005, 33 : 50 - 54
[2] Moxifloxacin and ciprofloxacin protect human respiratory epithelial cells against Streptococcus pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, and Haemophilus influenzae in vitro
Ulrich, M
Berger, J
Möller, JG
Döring, G
INFECTION, 2005, 33 (Suppl 2) : 50 - 54
[3] Pharmacodynamics of moxifloxacin and levofloxacin against Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae and Escherichia coli:: simulation of human plasma concentrations after intravenous dosage in an in vitro kinetic model
Odenholt, Inga
Cars, Otto
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 58 (05) : 960 - 965

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