In Vitro Activities of 21 Antimicrobial Agents Alone and in Combination with Aminoglycosides or Fluoroquinolones against Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolates Causing Bacteremia

被引：18
|
作者：
Cha, Min Kyeong [1 ]
Kang, Cheol-In [2 ]
Kim, So Hyun [1 ,2 ]
Cho, Sun Young [2 ]
Ha, Young Eun [2 ]
Wi, Yu Mi [3 ]
Chung, Doo Ryeon [1 ,2 ]
Peck, Kyong Ran [2 ]
Song, Jae-Hoon [1 ,2 ]
机构：
[1] APFID, Seoul, South Korea
[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Infect Dis, Seoul, South Korea
[3] Sungkyunkwan Univ, Sch Med, Samsung Changwon Hosp, Div Infect Dis, Chang Won, South Korea
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
ANTIBIOTIC-THERAPY; MOLECULAR EPIDEMIOLOGY; SEPTIC SHOCK; RISK-FACTORS; INFECTIONS; SEPSIS; MONOTHERAPY; IMPACT;
D O I：
10.1128/AAC.01121-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We evaluated the in vitro activity of various antimicrobials alone and in combination against 291 extended-spectrum-beta-lactamase-producing Escherichia coli (ESBL-EC) isolates causing bacteremia in South Korean hospitals. Ceftazidime, cefepime, and piperacillin-tazobactam in combination with amikacin showed greater activity than found in combination with ciprofloxacin. In settings with a high prevalence of ESBL-producing pathogens, combination aminoglycoside antimicrobial therapy, especially with amikacin, may be considered for empirical therapy against suspected Gram-negative sepsis as a carbapenem-saving strategy.
引用
收藏
页码：5834 / 5837
页数：4
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