Use of isoflavone supplements is associated with reduced postmenopausal breast cancer risk

被引:31
|
作者
Boucher, Beatrice A. [1 ,2 ,3 ]
Cotterchio, Michelle [1 ,3 ]
Anderson, Laura N. [1 ]
Kreiger, Nancy [1 ,2 ,3 ]
Kirsh, Victoria A. [1 ,3 ]
Thompson, Lilian U. [2 ]
机构
[1] Canc Care Ontario, Prevent & Canc Control, Toronto, ON M5G 2L7, Canada
[2] Univ Toronto, Dept Nutr Sci, Toronto, ON, Canada
[3] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada
关键词
breast neoplasms; isoflavones; phytoestrogens; dietary supplements; plant preparations; DIETARY PHYTOESTROGEN INTAKE; HORMONE-RELATED SUPPLEMENTS; SOY INTAKE; INCLUDING ISOFLAVONES; PHYTO-ESTROGENS; SOYFOOD INTAKE; LIFE-STYLE; IN-VITRO; WOMEN; CANADA;
D O I
10.1002/ijc.27769
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Botanical supplements are widely used and contain diverse ingredients, including isoflavones. Food-based isoflavones have been associated with reduced breast cancer risk. However, no study has comprehensively evaluated supplements identified by isoflavone content and breast cancer risk. Associations between ever use of 28 isoflavone supplements and breast cancer risk in Ontario, Canada were evaluated using cases (n = 3,101) identified in 20022003 from the Ontario Cancer Registry and controls (n = 3,471) identified through random digit dialing methods. Multivariate logistic regression was used to estimate age-adjusted odds ratio (AOR) and 95% confidence intervals (CI). Several individual supplements were associated with reduced breast cancer risk (e.g., Natural HRT; AOR = 0.39; 95% CI: 0.22, 0.69; nusers = 58). Use of any isoflavone supplements was associated with reduced risk when =3 were ever used (AOR = 0.68; 95% CI: 0.54, 0.86; nusers = 332; ptrend = 0.008) or any was taken >5 years (AOR = 0.75; 95% CI: 0.60, 0.94; nusers = 325; ptrend = 0.01); high content supplements were consistently associated with reduced risk. Risk reduction was confined to postmenopausal breast cancer for both individual and combined supplements, and was strongest in the latter among high content users who ever took =3 supplements (AOR = 0.55; 95% CI: 0.38, 0.81; nusers = 118; ptrend = 0.04) or any >5 years (AOR = 0.47; 95% CI: 0.27, 0.81; nusers = 60; ptrend = 0.03). Associations did not differ by estrogen-progesterone tumor receptor status. In conclusion, isoflavone supplements were associated with decreased postmenopausal breast cancer risk. Further research to examine these novel findings is warranted, given the low supplement use and potential limitations of our results.
引用
收藏
页码:1439 / 1450
页数:12
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