No Differences in Hippocampal Volume between Carriers and Non-Carriers of the ApoE ε4 and ε2 Alleles in Young Healthy Adolescents

被引：36

作者：

Khan, Wasim ^{[1
,2
,3
]}

Giampietro, Vincent ^{[1
]}

Ginestet, Cedric ^{[1
,2
]}

Dell'Acqua, Flavio ^{[1
,2
,3
]}

Bouls, David ^{[1
,2
,3
]}

Newhouse, Steven ^{[1
,2
,3
]}

Dobson, Richard ^{[1
,2
,3
]}

Banaschewski, Tobias ^{[4
,5
]}

Barker, Gareth J. ^{[1
]}

Bokde, Arun L. W. ^{[8
,9
]}

Buechel, Christian ^{[6
]}

Conrod, Patricia ^{[1
,7
]}

Flor, Herta ^{[4
,5
]}

Frouin, Vincent ^{[16
]}

Garavan, Hugh ^{[19
,20
,21
]}

Gowland, Penny ^{[22
]}

Heinz, Anreas ^{[7
]}

Ittermann, Bernd ^{[10
]}

Lemaitrek, Herve ^{[11
,12
]}

Nees, Frauke ^{[4
,5
]}

Paus, Tomas ^{[13
,14
,15
]}

Pausova, Zdenka ^{[18
]}

Rietschel, Marcella ^{[4
,5
]}

Smolka, Michael N. ^{[17
]}

Stroehle, Andreas ^{[7
]}

Gallinat, Jean ^{[7
]}

Westman, Eric ^{[23
]}

Schumann, Gunther ^{[1
,2
]}

Lovestone, Simon ^{[1
,2
,3
]}

Simmons, Andrew ^{[1
,2
,3
]}

机构：

[1] Kings Coll London, Inst Psychiat, London SE5 8AF, England

[2] Kings Coll London, NIHR Biomed Res Ctr Mental Hlth, London SE5 8AF, England

[3] Kings Coll London, NIHR Biomed Res Unit Dementia, London SE5 8AF, England

[4] Cent Inst Mental Hlth, Mannheim, Germany

[5] Heidelberg Univ, Med Fac Mannheim, Heidelberg, Germany

[6] Univ Klinikum Hamburg Eppendorf, Hamburg, Germany

[7] Charite, Dept Psychiat & Psychotherapy, D-13353 Berlin, Germany

[8] Univ Dublin Trinity Coll, Sch Med, Inst Neurosci, Dublin 2, Ireland

[9] Univ Dublin Trinity Coll, Sch Med, Discipline Psychiat, Dublin 2, Ireland

[10] Phys Tech Bundesanstalt, Berlin, Germany

[11] Univ Paris 11, INSERM, INSERM CEA Imaging & Psychiat U1000, F-91405 Orsay, France

[12] Univ Paris 05, AP HP Dept Adolescent Psychopathol & Med, Paris, France

[13] Univ Toronto, Rotman Res Inst, Toronto, ON, Canada

[14] Univ Nottingham, Sch Psychol, Nottingham NG7 2RD, England

[15] McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada

[16] Commissariat Energie Atom & Energies Alternat, Neurospin, Paris, France

[17] Tech Univ Dresden, Dept Psychiat & Psychotherapy, Neuroimaging Ctr, Dresden, Germany

[18] Univ Toronto, Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[19] Univ Dublin Trinity Coll, Inst Neurosci, Dublin 2, Ireland

[20] Univ Vermont, Dept Psychiat, Burlington, VT USA

[21] Univ Vermont, Dept Psychol, Burlington, VT 05405 USA

[22] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England

[23] Karolinska Inst, Stockholm, Sweden

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2014年 / 40卷 / 01期

关键词：

Apolipoprotein E; hippocampal volume; magnetic resonance imaging; young healthy adolescents; APOLIPOPROTEIN-E EPSILON-4; MILD COGNITIVE IMPAIRMENT; GRAY-MATTER VOLUME; E E4 ALLELE; ALZHEIMERS-DISEASE; E GENOTYPE; GENETIC RISK; CORTICAL THICKNESSES; BRAIN ATROPHY; MRI;

D O I：

10.3233/JAD-131841

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE epsilon 4 or epsilon 2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these polymorphisms may only become apparent in later life.

引用

页码：37 / 43

页数：7

共 50 条

[1] Tract Based Spatial Statistic Reveals No Differences in White Matter Microstructural Organization between Carriers and Non-Carriers of the APOE ε4 and ε2 Alleles in Young Healthy Adolescents
Dell'Acqua, Flavio
Khan, Wasim
Gottlieb, Natalie
Giampietro, Vincent
Ginestet, Cedric
Bouls, David
Newhouse, Steven
Dobson, Richard
Banaschewski, Tobias
Barker, Gareth J.
Bokde, Arun L. W.
Buechel, Christian
Conrod, Patricia
Flor, Herta
Frouin, Vincent
Garavan, Hugh
Gowlands, Penny
Heinz, Anreas
Lemaitre, Herve
Nees, Frauke
Paus, Tomas
Pausova, Zdenka
Rietschel, Marcella
Smolka, Michael N.
Stroehle, Andreas
Gallinat, Jean
Westman, Eric
Schumann, Gunther
Lovestone, Simon
Simmons, Andrew
[J]. JOURNAL OF ALZHEIMERS DISEASE, 2015, 47 (04) : 977 - 984
[2] Differences in Hippocampal Brain Connectivity between APOE4 Carriers and Non-Carriers among Healthy Older Adults
Tarawneh, Rawan
Cowan, Ronald L.
Atalla, Sebastian
Monroe, Todd
[J]. ANNALS OF NEUROLOGY, 2019, 86 : S154 - S154
[3] Differences in Grey Matter Concentrations and Functional Connectivity between Young Carriers and Non-Carriers of the APOE ε4 Genotype
Munoz-Neira, Carlos
Zeng, Jianmin
Kucikova, Ludmila
Huang, Weijie
Xiong, Xiong
Muniz-Terrera, Graciela
Ritchie, Craig
O'Brien, John T.
Su, Li
[J]. JOURNAL OF CLINICAL MEDICINE, 2024, 13 (17)
[4] White Matter Differences between Healthy Young ApoE4 Carriers and Non-Carriers Identified with Tractography and Support Vector Machines
O'Dwyer, Laurence
Lamberton, Franck
Matura, Silke
Scheibe, Monika
Miller, Julia
Rujescu, Dan
Prvulovic, David
Hampel, Harald
[J]. PLOS ONE, 2012, 7 (04):
[5] Hippocampal Volume Differences Between Healthy Young Apolipoprotein E ε2 and ε4 Carriers
Alexopoulos, Panagiotis
Richter-Schmidinger, Tanja
Horn, Marco
Maus, Sebastian
Reichel, Martin
Sidiropoulos, Christos
Rhein, Cosima
Lewczuk, Piotr
Doerfler, Arnd
Kornhuber, Johannes
[J]. JOURNAL OF ALZHEIMERS DISEASE, 2011, 26 (02) : 207 - 210
[6] Structural brain volume differences between cognitively intact ApoE4 carriers and non-carriers across the lifespan
Ryan J.Piers
[J]. Neural Regeneration Research, 2018, 13 (08) : 1309 - 1312
[7] Structural brain volume differences between cognitively intact ApoE4 carriers and non-carriers across the lifespan
Piers, Ryan J.
[J]. NEURAL REGENERATION RESEARCH, 2018, 13 (08) : 1309 - 1312
[8] A Systems View of the Differences between APOE ε4 Carriers and Non-carriers in Alzheimer's Disease
Jiang, Shan
Tang, Ling
Zhao, Na
Yang, Wanling
Qiu, Yu
Chen, Hong-Zhuan
[J]. FRONTIERS IN AGING NEUROSCIENCE, 2016, 8
[9] Reduced Hippocampal Volume in Healthy Young ApoE4 Carriers: An MRI Study
O'Dwyer, Laurence
Lamberton, Franck
Matura, Silke
Tanner, Colby
Scheibe, Monika
Miller, Julia
Rujescu, Dan
Prvulovic, David
Hampel, Harald
[J]. PLOS ONE, 2012, 7 (11):
[10] Increased hippocampal activation in ApoE-4 carriers and non-carriers with amnestic mild cognitive impairment
Tran, Tammy T.
Speck, Caroline L.
Pisupati, Aparna
Gallagher, Michela
Bakker, Arnold
[J]. NEUROIMAGE-CLINICAL, 2017, 13 : 237 - 245

← 1 2 3 4 5 →