Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination

被引：0
|
作者：
Mbatchi, Litaty Cephanoee [1 ,2 ,3 ]
Schmitt, Antonin [4 ,5 ]
Thomas, Fabienne [4 ,5 ]
Cazaubon, Yoann [3 ]
Robert, Jacques [6 ]
Lumbroso, Serge [1 ]
Brouillet, Jean-Paul [1 ,2 ]
Pourquier, Philippe [2 ]
Chatelut, Etienne [4 ,5 ]
Boyer, Jean-Christophe [1 ]
Evrard, Alexandre [1 ,2 ,3 ]
机构：
[1] Ctr Hosp Univ Nimes, Hop Caremeau, Biochim Lab, Nimes, France
[2] INSERM, U1194, Inst Rech Cancerol Montpellier, F-34298 Montpellier, France
[3] Univ Montpellier, Fac Pharm, Lab Pharmacocinet, F-34059 Montpellier, France
[4] Inst Claudius Regaud, EA4553, Toulouse, France
[5] Univ Toulouse 3, F-31062 Toulouse, France
[6] Univ Bordeaux, Inst Bergonie, INSERM U916, Bordeaux, France
来源：
PHARMACOGENOMICS | 2015年 / 16卷 / 13期
关键词：
carboplatin; drug metabolism; hematotoxicity; paclitaxel; pregnane X-receptor; PXR; SLCO1B3; SNP; PREGNANE-X-RECEPTOR; CELL LUNG-CANCER; OVARIAN-CANCER; MELTING ANALYSIS; PHASE-I; PHARMACOKINETICS; CHEMOTHERAPY; ASSOCIATION; TOXICITY; PHARMACOGENETICS;
D O I：
10.2217/PGS.15.84
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: The goal of our study was to assess the impact of patients' genetic background on their sensitivity to carboplatin/paclitaxel hematotoxicity. Patients & methods: Parameters describing sensitivity to neutropenia and to thrombocytopenia of 201 patients were extracted from a previous pharmacokinetic/pharmacodynamics analysis, in order to assess their association with 52 candidates SNPs in 18 genes. Results: Carriers of a T allele of SLCO1B3-rs4149117 were 19% less sensitive to thrombocytopenia than the homozygotes for the G allele (p = 0.00279). Carriers of two copies of the ATG haplotypes of NR1I2-rs1523130, rs3814055 and rs1523127 were 19% less sensitive to thrombocytopenia than those harboringother haplotypes (p = 0.025). Conclusion: Our results revealed the importance of SLCO1B3 and NR1I2 in the sensitivity to carboplatin/paclitaxel thrombocytopenia.
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收藏
页码：1439 / 1450
页数：12
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