Pro-Antimicrobial Networks via Degradable Acetals (PANDAs) Using Thiol-Ene Photopolymerization

被引：22
|
作者：
Amato, Dahlia N. [1 ]
Amato, Douglas V. [1 ]
Mavrodi, Olga V. [2 ]
Martin, William B. [1 ]
Swilley, Sarah N. [1 ]
Parsons, Keith H. [1 ]
Mavrodi, Dmitri V. [2 ]
Patton, Derek L. [1 ]
机构：
[1] Univ Southern Mississippi, Sch Polymers & High Performance Mat, Hattiesburg, MS 39406 USA
[2] Univ Southern Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA
来源：
ACS MACRO LETTERS | 2017年 / 6卷 / 02期
基金：
美国国家科学基金会;
关键词：
CROSS-LINKED POLYESTERS; CONTROLLED-RELEASE; ANTIBACTERIAL ACTIVITIES; POLYMERIC PRODRUG; EXTENDED-RELEASE; SALICYLIC-ACID; ESSENTIAL OILS; IN-VITRO; ANTIOXIDANT; BEHAVIOR;
D O I：
10.1021/acsmacrolett.7b00009
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
We describe the synthesis of pro-antimicrobial networks via degradable acetals (PANDAs) as a new paradigm for sequestration and triggered release of volatile, bioactive aldehydes. PANDAS derived from diallyl p-chlorobenzaldehyde acetal degrade and release p-chlorobenzaldehyde as an antibacterial and antifungal agent under mild conditions (pH 7.4/high humidity). We show that PANDAS enable facile access to materials with tunable release profiles, potent antimicrobial activity without triggering antimicrobial resistance, and minimal cytotoxicity.
引用
收藏
页码：171 / 175
页数：5
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