Targeting the Lung Using siRNA and Antisense Based Oligonucleotides

被引：15
|
作者：
Moschos, Sterghios A. [2 ]
Spinks, Karen [2 ]
Williams, Andrew E. [3 ]
Lindsay, Mark A. [1 ,3 ]
机构：
[1] Univ Manchester, Wythenshawe Hosp, Sch Translat Med, Resp Res Grp, Manchester M23 9LT, Lancs, England
[2] Pfizer Global Res & Dev, Sandwich CT13 9NU, Kent, England
[3] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Biopharmaceut Res Grp, London SW3 6LY, England
来源：
CURRENT PHARMACEUTICAL DESIGN | 2008年 / 14卷 / 34期
基金：
英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
siRNA; antisense; airways; lung; RNA interference;
D O I：
10.2174/138161208786898851
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The accessibility to topical administration through inhalation, combined with its large surface area, has led to speculation that the lung might offer an ideal target for the application of oligonucleotide based therapeutics. In this review, we shall critically examine the challenges facing antisense and siRNA based approaches for target validation in vivo and as potential therapeutics. In particular, we shall discuss the antisense and siRNA based approaches in relation to factors such as delivery, distribution, stability, off-target effects, unwanted immune responses and the selection of the optimum mRNA targets.
引用
收藏
页码：3620 / 3627
页数：8
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