The complement system in ischemia-reperfusion injuries

被引：109
|
作者：
Gorsuch, William B.
Chrysanthou, Elvina [2 ]
Schwaeble, Wilhelm J. [2 ]
Stahl, Gregory L. [1 ]
机构：
[1] Harvard Univ, Ctr Expt Therapeut & Reperfus Injury, Dept Anesthesiol Perioperat & Pain Med, Brigham & Womens Hosp,Med Sch,Harvard Inst Med, Boston, MA 02115 USA
[2] Univ Leicester, Dept Infect Immun & Inflammat, Leicester, Leics, England
来源：
IMMUNOBIOLOGY | 2012年 / 217卷 / 11期
基金：
英国医学研究理事会;
关键词：
Myocardial; Inflammation; Lectin; Inhibitor; Gastrointestinal; MANNOSE-BINDING LECTIN; C1 ESTERASE INHIBITOR; ACUTE MYOCARDIAL-INFARCTION; SERINE PROTEASE-2 MASP-2; REMOTE ORGAN INJURY; COBRA VENOM FACTOR; SKELETAL-MUSCLE; ISCHEMIA/REPERFUSION INJURY; C1-ESTERASE INHIBITOR; MONOCLONAL-ANTIBODY;
D O I：
10.1016/j.imbio.2012.07.024
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tissue injury and inflammation following ischemia and reperfusion of various organs have been recognized for many years. Many reviews have been written over the last several decades outlining the role of complement in ischemia/reperfusion injury. This short review provides a current state of the art knowledge on the complement pathways activated, complement components involved and a review of the clinical biologics/inhibitors used in the clinical setting of ischemia/reperfusion. This is not a complete review of the complement system in ischemia and reperfusion injury but will give the reader an updated view point of the field, potential clinical use of complement inhibitors, and the future studies needed to advance the field. (C) 2012 Elsevier GmbH. All rights reserved.
引用
收藏
页码：1026 / 1033
页数：8
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