Syntheses of 5′-amino-2′,5′-dideoxy-2′,2′-difluorocytidine derivatives as novel anticancer nucleoside analogs

被引：6

作者：

Labroli, Marc A. ^{[1
]}

Dwyer, Michael P. ^{[2
]}

Shen, Ruichao ^{[3
]}

Popovici-Muller, Janeta ^{[3
]}

Pu, Qinglin ^{[3
]}

Richard, Judson ^{[3
]}

Rosner, Kristen ^{[3
]}

Paruch, Kamil ^{[1
]}

Guzi, Timothy J. ^{[3
]}

机构：

[1] Merck Res Labs, Kenilworth, NJ 07033 USA

[2] Merck Res Labs, Rahway, NJ 07065 USA

[3] Merck Res Labs, Boston, MA 02115 USA

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 03期

关键词：

Nucleoside; Gemcitabine; Reductive amination; Anticancer; GEMCITABINE; TOXICITY; CANCER;

D O I：

10.1016/j.tetlet.2013.11.018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel class of 5'-amino-2',5'-dideoxy-2',2'-difluorocytidine derivatives has been synthesized in order to identify anticancer nucleoside analogs. Several synthetic routes were devised and implemented which relied upon either S(N)2 displacement or reductive amination to provide the desired derivatives. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：598 / 602

页数：5

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