Recent trends on hydrogel based drug delivery systems for infectious diseases

被引:37
|
作者
Vashist, Arti [1 ]
Kaushik, Ajeet [1 ]
Vashist, Atul [2 ]
Jayant, Rahul Dev [1 ]
Tomitaka, Asahi [1 ]
Ahmad, Sharif [3 ]
Gupta, Y. K. [4 ]
Nair, Madhavan [1 ]
机构
[1] Florida Int Univ, Inst Neuroimmune Pharmacol, Herbert Wertheim Coll Med, Ctr Personalized Nanomed, Miami, FL 33199 USA
[2] All India Inst Med Sci, Dept Biotechnol, New Delhi 110029, India
[3] Dept Chem, Mat Res Lab, New Delhi 110025, India
[4] All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India
关键词
SOLID LIPID NANOPARTICLES; STIMULI-RESPONSIVE NANOCARRIERS; THERMAL-SENSITIVE HYDROGEL; BRAIN DELIVERY; INFLUENZA-VIRUS; POLYMERIC MICELLES; DIAGNOSTIC-TESTS; TUBERCULOSIS; MALARIA; CARRIERS;
D O I
10.1039/c6bm00276e
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Since centuries, the rapid spread and cure of infectious diseases have been a major concern to the progress and survival of humans. These diseases are a global burden and the prominent cause for worldwide deaths and disabilities. Nanomedicine has emerged as the most excellent tool to eradicate and halt their spread. Various nanoformulations (NFs) using advanced nanotechnology are in demand. Recently, hydrogel and nanogel based drug delivery devices have posed new prospects to simulate the natural intelligence of various biological systems. Owing to their unique porous interpenetrating network design, hydrophobic drug incorporation and stimulus sensitivity hydrogels owe excellent potential as targeted drug delivery systems. The present review is an attempt to highlight the recent trends of hydrogel based drug delivery systems for the delivery of therapeutic agents and diagnostics for major infectious diseases including acquired immune deficiency syndrome (AIDS), malaria, tuberculosis, influenza and ebola. Future prospects and challenges are also described.
引用
收藏
页码:1535 / 1553
页数:19
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