One-step radiosynthesis of 4-nitrophenyl 2-[18F]fluoropropionate ([18F]NFP); improved preparation of radiolabeled peptides for PET imaging

被引：23

作者：

Haskali, Mohammad B. ^{[1
,2
,3
,4
]}

Roselt, Peter D. ^{[3
,4
]}

Karas, John A. ^{[2
]}

Noonan, Wayne ^{[3
,4
]}

Wichmann, Christian W. ^{[3
,4
]}

Katsifis, Andrew ^{[5
]}

Hicks, Rodney J. ^{[3
,4
]}

Hutton, Craig A. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Sch Chem, Melbourne, Vic 3010, Australia

[2] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Melbourne, Vic 3010, Australia

[3] Peter MacCallum Canc Ctr, Ctr Mol Imaging, Melbourne, Vic, Australia

[4] Peter MacCallum Canc Ctr, Translat Res Lab, Melbourne, Vic, Australia

[5] ANSTO LifeSci, Sydney, NSW, Australia

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2013年 / 56卷 / 14期

基金：

澳大利亚研究理事会;

关键词：

radiofluorination; PET imaging; fluoropropionate; RGD peptide; F-18]fluoride; INTEGRIN; F-18; EXPRESSION; ANTAGONISTS; ACTIVATION; THERAPY; TUMORS;

D O I：

10.1002/jlcr.3111

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The versatile F-18-labeled prosthetic group, 4-nitrophenyl 2-[F-18]fluoropropionate ([F-18]NFP), was synthesized in a single step in 45min from 4-nitrophenyl 2-bromopropionate, with a decay corrected radiochemical yield of 26.2%+/- 2.2%. Employing this improved synthesis of [F-18]NFP, [F-18]GalactoRGD the current gold standard' tracer for imaging the expression of (V3) integrin was prepared with high specific activity in 90min and 20% decay corrected radiochemical yield from [F-18]fluoride.

引用

页码：726 / 730

页数：5

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